Zn2+-Selective Switch of Duplex to Hairpin DNA

Stephanie A. Sander; Alexandra K. Van Hall; Janet R. Morrow

doi:10.1021/ic503074p

Zn²⁺-Selective Switch of Duplex to Hairpin DNA

Stephanie A. Sander
, Alexandra K. Van Hall
, Janet R. Morrow

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

DNA sequences that undergo large changes in secondary structure upon binding of small molecules are the basis for molecular switches. Here we report a Zn²⁺ complex that promotes the conversion of a fully complementary DNA double helix into DNA hairpins. The conformational switch is promoted by an isolated Zn²⁺ complex or by free ZnCl₂ and a macrocyclic ligand. The switch is selective for Zn²⁺ over biologically relevant transition-metal ions including Cu²⁺ and Fe²⁺. The dual ligand/DNA switch is an approach that may improve the selectivity for metal-ion-sensing applications.

Original language	English
Pages (from-to)	3084-3086
Number of pages	3
Journal	Inorganic Chemistry
Volume	54
Issue number	7
DOIs	https://doi.org/10.1021/ic503074p
State	Published - Apr 6 2015

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title = "Zn2+-Selective Switch of Duplex to Hairpin DNA",

abstract = "DNA sequences that undergo large changes in secondary structure upon binding of small molecules are the basis for molecular switches. Here we report a Zn2+ complex that promotes the conversion of a fully complementary DNA double helix into DNA hairpins. The conformational switch is promoted by an isolated Zn2+ complex or by free ZnCl2 and a macrocyclic ligand. The switch is selective for Zn2+ over biologically relevant transition-metal ions including Cu2+ and Fe2+. The dual ligand/DNA switch is an approach that may improve the selectivity for metal-ion-sensing applications.",

author = "Sander, \{Stephanie A.\} and \{Van Hall\}, \{Alexandra K.\} and Morrow, \{Janet R.\}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

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T1 - Zn2+-Selective Switch of Duplex to Hairpin DNA

AU - Sander, Stephanie A.

AU - Van Hall, Alexandra K.

AU - Morrow, Janet R.

PY - 2015/4/6

Y1 - 2015/4/6

N2 - DNA sequences that undergo large changes in secondary structure upon binding of small molecules are the basis for molecular switches. Here we report a Zn2+ complex that promotes the conversion of a fully complementary DNA double helix into DNA hairpins. The conformational switch is promoted by an isolated Zn2+ complex or by free ZnCl2 and a macrocyclic ligand. The switch is selective for Zn2+ over biologically relevant transition-metal ions including Cu2+ and Fe2+. The dual ligand/DNA switch is an approach that may improve the selectivity for metal-ion-sensing applications.

AB - DNA sequences that undergo large changes in secondary structure upon binding of small molecules are the basis for molecular switches. Here we report a Zn2+ complex that promotes the conversion of a fully complementary DNA double helix into DNA hairpins. The conformational switch is promoted by an isolated Zn2+ complex or by free ZnCl2 and a macrocyclic ligand. The switch is selective for Zn2+ over biologically relevant transition-metal ions including Cu2+ and Fe2+. The dual ligand/DNA switch is an approach that may improve the selectivity for metal-ion-sensing applications.

UR - https://www.scopus.com/pages/publications/84926475265

U2 - 10.1021/ic503074p

DO - 10.1021/ic503074p

M3 - Article

C2 - 25751091

AN - SCOPUS:84926475265

SN - 0020-1669

VL - 54

SP - 3084

EP - 3086

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 7

ER -

Zn²⁺-Selective Switch of Duplex to Hairpin DNA

Abstract

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