Abstract
We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.
| Original language | English |
|---|---|
| Article number | 050506 |
| Journal | Journal of Biomedical Optics |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2012 |
Keywords
- Anatomic imaging
- Half-time image reconstruction
- Photoacoustic computed tomography
- Small-animal imaging
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