Abstract
A water-soluble nitrosyl complex with large two-photon absorption was synthesized by incorporating a two-photon absorbing chromophore with tetra(ethylene glycol) units, into the Roussin's red salt. The nitrosyl complex exhibits quenched emission due to energy transfer from the two-photon chromophore to the Roussin's red salt. The nitric oxide (NO) release induced by one- or two-photon irradiation was detected by EPR spectroscopy with a chemical probe, the Fe(ll)-N-(dithiocarbamoyl)-N-methyl-D-glucamine (Fe-MGD) complex. Increased one- or two-photon excited fluorescence, with a concomitant photochemical release of NO, was observed upon one- or two-photon light irradiation. With the observed light-dependent cytotoxicity against cancer cells of the water-soluble nitrosyl complex, it was demonstrated that two-photon-functionalized nitrosyl complexes can be effective NO donors for light-activated treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 389-398 |
| Number of pages | 10 |
| Journal | Molecular Pharmaceutics |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2008 |
Keywords
- Light-dependent cytotoxicity
- Nitrosyl complex
- NO release
- Two-photon absorption
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