TY - GEN
T1 - Vortex dynamics of ruptured and unruptured intracranial aneurysms
AU - Varble, Nicole
AU - Trylesinski, Gabriel
AU - Xiang, Jianping
AU - Meng, Hui
N1 - Publisher Copyright:
Copyright © 2014 by ASME.
PY - 2014
Y1 - 2014
N2 - Intracranial aneurysms are a potentially devastating pathological dilation of brain arteries that affect 1-5 % of the population. In this study we investigated the vortex structures of both unruptured and ruptured intracranial aneurysms as a discriminating property. We performed pulsatile computational fluid dynamic simulations on 204 patient-specific aneurysm models (57 ruptured and 147 unruptured) derived from patient angiographic imaging. Using Q-criterion we analyzed the coherent structures both throughout the aneurysm volume and at the wall. The relative surface area with positive Q values (indicating vortices at the wall) was able to differentiate ruptured and unruptured aneurysms. For the first time, in a large patient cohort, mechanistic fluid analysis is leading to insights into rupture pathways.
AB - Intracranial aneurysms are a potentially devastating pathological dilation of brain arteries that affect 1-5 % of the population. In this study we investigated the vortex structures of both unruptured and ruptured intracranial aneurysms as a discriminating property. We performed pulsatile computational fluid dynamic simulations on 204 patient-specific aneurysm models (57 ruptured and 147 unruptured) derived from patient angiographic imaging. Using Q-criterion we analyzed the coherent structures both throughout the aneurysm volume and at the wall. The relative surface area with positive Q values (indicating vortices at the wall) was able to differentiate ruptured and unruptured aneurysms. For the first time, in a large patient cohort, mechanistic fluid analysis is leading to insights into rupture pathways.
UR - https://www.scopus.com/pages/publications/84926059415
U2 - 10.1115/DETC2014-35713
DO - 10.1115/DETC2014-35713
M3 - Conference contribution
AN - SCOPUS:84926059415
T3 - Proceedings of the ASME Design Engineering Technical Conference
BT - 16th International Conference on Advanced Vehicle Technologies; 11th International Conference on Design Education; 7th Frontiers in Biomedical Devices
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2014
Y2 - 17 August 2014 through 20 August 2014
ER -