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Virtual gene: Using correlations between genes to select informative genes on microarray datasets

  • SUNY Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

Gene Selection is one class of most used data analysis algorithms on microarray datasets. The goal of gene selection algorithms is to filter out a small set of informative genes that best explains experimental variations. Traditional gene selection algorithms are mostly single-gene based. Some discriminative scores are calculated and sorted for each gene. Top ranked genes are then selected as informative genes for further study. Such algorithms ignore completely correlations between genes, although such correlations is widely known. Genes interact with each other through various pathways and regulative networks. In this paper, we propose to use, instead of ignoring, such correlations for gene selection. Experiments performed on three public available datasets show promising results.

Original languageEnglish
Title of host publicationTransactions on Computational Systems Biology II
PublisherSpringer Verlag
Pages138-152
Number of pages15
ISBN (Print)3540294015, 9783540294016
DOIs
StatePublished - 2005
EventInternational Workshop on Bioinformatics Research and Applications, IWBRA 2005 - Atlanta, GA, United States
Duration: May 22 2005 → May 24 2005

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3680 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

ConferenceInternational Workshop on Bioinformatics Research and Applications, IWBRA 2005
Country/TerritoryUnited States
CityAtlanta, GA
Period05/22/05 → 05/24/05

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