Vanadate induction of pancreatic amylase mRNA in diabetic rats

T. M. Johnson; M. H. Meisler; M. I. Bennett; G. R. Willsky

doi:10.2337/diab.39.6.757

Vanadate induction of pancreatic amylase mRNA in diabetic rats

T. M. Johnson
, M. H. Meisler
, M. I. Bennett
, G. R. Willsky

Biochemistry

University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Amylase activity and mRNA abundance are reduced to <1% of normal levels in diabetic rat pancreas. Administration of vanadate in drinking water restored normal amylase activity and amylase mRNA levels. These results demonstrate an effect of vanadate on pancreatic acinar cells and suggest that vanadate can mimic the effect of insulin on transcription of the pancreatic amylase gene.

Original language	English
Pages (from-to)	757-759
Number of pages	3
Journal	Diabetes
Volume	39
Issue number	6
DOIs	https://doi.org/10.2337/diab.39.6.757
State	Published - 1990

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10.2337/diab.39.6.757

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@article{0cc8fba44fb44362858d4a993563558e,

title = "Vanadate induction of pancreatic amylase mRNA in diabetic rats",

abstract = "Amylase activity and mRNA abundance are reduced to <1\% of normal levels in diabetic rat pancreas. Administration of vanadate in drinking water restored normal amylase activity and amylase mRNA levels. These results demonstrate an effect of vanadate on pancreatic acinar cells and suggest that vanadate can mimic the effect of insulin on transcription of the pancreatic amylase gene.",

author = "Johnson, \{T. M.\} and Meisler, \{M. H.\} and Bennett, \{M. I.\} and Willsky, \{G. R.\}",

year = "1990",

doi = "10.2337/diab.39.6.757",

language = "English",

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pages = "757--759",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association Inc.",

number = "6",

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T1 - Vanadate induction of pancreatic amylase mRNA in diabetic rats

AU - Johnson, T. M.

AU - Meisler, M. H.

AU - Bennett, M. I.

AU - Willsky, G. R.

PY - 1990

Y1 - 1990

N2 - Amylase activity and mRNA abundance are reduced to <1% of normal levels in diabetic rat pancreas. Administration of vanadate in drinking water restored normal amylase activity and amylase mRNA levels. These results demonstrate an effect of vanadate on pancreatic acinar cells and suggest that vanadate can mimic the effect of insulin on transcription of the pancreatic amylase gene.

AB - Amylase activity and mRNA abundance are reduced to <1% of normal levels in diabetic rat pancreas. Administration of vanadate in drinking water restored normal amylase activity and amylase mRNA levels. These results demonstrate an effect of vanadate on pancreatic acinar cells and suggest that vanadate can mimic the effect of insulin on transcription of the pancreatic amylase gene.

UR - https://www.scopus.com/pages/publications/0025287443

U2 - 10.2337/diab.39.6.757

DO - 10.2337/diab.39.6.757

M3 - Article

C2 - 1693346

AN - SCOPUS:0025287443

SN - 0012-1797

VL - 39

SP - 757

EP - 759

JO - Diabetes

JF - Diabetes

IS - 6

ER -

Vanadate induction of pancreatic amylase mRNA in diabetic rats

Abstract

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