Validity of composite end points in clinical trials

Victor M. Montori; Gaietà Permanyer-Miralda; Ignacio Ferreira-González; Jason W. Busse; Valeria Pacheco-Huergo; Dianne Bryant; Jordi Alonso; Elie A. Akl; Antònia Domingo-Salvany; Edward Mills; Ping Wu; Holger J. Schünemann; Roman Jaeschke; Gordon H. Guyatt

doi:10.1136/bmj.330.7491.594

Validity of composite end points in clinical trials

Victor M. Montori
, Gaietà Permanyer-Miralda
, Ignacio Ferreira-González
, Jason W. Busse
, Valeria Pacheco-Huergo
, Dianne Bryant
, Jordi Alonso
, Elie A. Akl
, Antònia Domingo-Salvany
, Edward Mills
, Ping Wu
, Holger J. Schünemann
, Roman Jaeschke
, Gordon H. Guyatt

Department of Epidemiology and Environmental Health

Mayo Clinic Rochester, MN
Vall d'Hebron University Hospital
Autonomous University of Barcelona
McMaster University
Generalitat de Catalunya
Municipal Institute for Medical Research Hospital del Mar
SUNY Buffalo
Canadian College of Naturopathic Medicine

Research output: Contribution to journal › Review article › peer-review

368 Scopus citations

Abstract

Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?

Original language	English
Pages (from-to)	594-596
Number of pages	3
Journal	BMJ
Volume	330
Issue number	7491
DOIs	https://doi.org/10.1136/bmj.330.7491.594
State	Published - Mar 12 2005

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10.1136/bmj.330.7491.594

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title = "Validity of composite end points in clinical trials",

abstract = "Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?",

author = "Montori, \{Victor M.\} and Gaiet{\`a} Permanyer-Miralda and Ignacio Ferreira-Gonz{\'a}lez and Busse, \{Jason W.\} and Valeria Pacheco-Huergo and Dianne Bryant and Jordi Alonso and Akl, \{Elie A.\} and Ant{\`o}nia Domingo-Salvany and Edward Mills and Ping Wu and Sch{\"u}nemann, \{Holger J.\} and Roman Jaeschke and Guyatt, \{Gordon H.\}",

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T1 - Validity of composite end points in clinical trials

AU - Montori, Victor M.

AU - Permanyer-Miralda, Gaietà

AU - Ferreira-González, Ignacio

AU - Busse, Jason W.

AU - Pacheco-Huergo, Valeria

AU - Bryant, Dianne

AU - Alonso, Jordi

AU - Akl, Elie A.

AU - Domingo-Salvany, Antònia

AU - Mills, Edward

AU - Wu, Ping

AU - Schünemann, Holger J.

AU - Jaeschke, Roman

AU - Guyatt, Gordon H.

PY - 2005/3/12

Y1 - 2005/3/12

N2 - Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?

AB - Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?

UR - https://www.scopus.com/pages/publications/20144373791

U2 - 10.1136/bmj.330.7491.594

DO - 10.1136/bmj.330.7491.594

M3 - Review article

C2 - 15761002

AN - SCOPUS:20144373791

SN - 0959-8146

VL - 330

SP - 594

EP - 596

JO - BMJ

JF - BMJ

IS - 7491

ER -

Validity of composite end points in clinical trials

Abstract

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