TY - JOUR
T1 - Validation of the HERMES-24 Score for Outcome Prediction Post Large Vessel Occlusion Treatment in Later Time Window
AU - Tanaka, Koji
AU - Brown, Scott
AU - Albers, Gregory W.
AU - Jovin, Tudor G.
AU - Lansberg, Maarten G.
AU - Nogueira, Raul G.
AU - Goyal, Mayank
AU - Hill, Michael D.
AU - Menon, Bijoy K.
AU - Jadhav, Ashutosh P.
AU - Haussen, Diogo C.
AU - Martins, Sheila C.O.
AU - Rebello, Leticia C.
AU - Ribo, Marc
AU - Turk, Aquilla S.
AU - Siddiqui, Adnan H.
AU - Liebeskind, David S.
AU - Heit, Jeremy J.
AU - Marks, Michael P.
AU - Demchuk, Andrew M.
AU - Bonafe, Alain
AU - Budzik, Ronald F.
AU - Bhuva, Parita
AU - Christensen, Soren
AU - Cognard, Christophe
AU - Hanel, Ricardo A.
AU - Hassan, Ameer E.
AU - Leslie-Mazwi, Thabele
AU - Mctaggart, Ryan A.
AU - Millán, Monica
AU - Ortega-Gutierrez, Santiago
AU - Shuaib, Ashfaq
AU - Sila, Cathy A.
AU - Torbey, Michel T.
AU - Kim-Tenser, May
AU - Tsai, Jenny P.
AU - Yavagal, Dileep R.
N1 - Publisher Copyright:
© 2025 American Academy of Neurology.
PY - 2025/8/12
Y1 - 2025/8/12
N2 - Background and ObjectivesThe Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials (HERMES)-24 score is highly predictive of outcomes after anterior circulation large vessel occlusion (LVO) treatment, irrespective of intervention in the early time window. Recent evidence has further broadened the eligibility of endovascular therapy (EVT) to patients with late presentation or unwitnessed onset including those with stroke-on-awakening. We aimed to investigate the prediction ability of the HERMES-24 score in patients with anterior circulation LVO and small ischemic core presenting in the late time window from last seen normal.MethodsData are from the Analysis of Pooled Data from Randomized Studies of Thrombectomy More Than 6 Hours After Last Known Well collaboration, a patient-level meta-analysis of 6 randomized trials of EVT beyond 6 hours after last known well, with an enrollment period from September 2014 to March 2019. Patients who were also part of the HERMES collaboration data set were excluded from the analyses. The HERMES-24 score was calculated as the sum of the patient's age/10 and NIH Stroke Scale (NIHSS) score at 24 hours after randomization. The predictive ability of the score for a 90-day outcome (modified Rankin Scale [mRS] scores ≤2 and ≤3, ordinal mRS score, and mortality) was investigated.ResultsAmong 435 patients (48.5% men, median age 71 years), the median onset-to-randomization time was 654 (interquartile range 516-849) minutes and the median baseline NIHSS score was 16 (interquartile range 13-21). The HERMES-24 score was predictive of 90-day mRS scores ≤2 and ≤3, ordinal mRS score, and mortality in both the EVT arm (n = 223, c-statistic [95% CI] 0.917 [0.875-0.944], 0.895 [0.853-0.938], 0.820 [0.745-0.891], and 0.849 [0.776-0.922], respectively) and the control arm (n = 212, c-statistic [95% CI] 0.921 [0.872-0.969], 0.879 [0.827-0.930], 0.805 [0.746-0.852], and 0.805 [0.738-0.871], respectively).DiscussionThe HERMES-24 score was highly predictive of 90-day outcome among patients with stroke due to LVO and small ischemic core for those presenting in the late time window, irrespective of intervention. This score must be further validated in a real-world clinical setting if it is applicable to all patients with LVO admitted in late time windows.
AB - Background and ObjectivesThe Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials (HERMES)-24 score is highly predictive of outcomes after anterior circulation large vessel occlusion (LVO) treatment, irrespective of intervention in the early time window. Recent evidence has further broadened the eligibility of endovascular therapy (EVT) to patients with late presentation or unwitnessed onset including those with stroke-on-awakening. We aimed to investigate the prediction ability of the HERMES-24 score in patients with anterior circulation LVO and small ischemic core presenting in the late time window from last seen normal.MethodsData are from the Analysis of Pooled Data from Randomized Studies of Thrombectomy More Than 6 Hours After Last Known Well collaboration, a patient-level meta-analysis of 6 randomized trials of EVT beyond 6 hours after last known well, with an enrollment period from September 2014 to March 2019. Patients who were also part of the HERMES collaboration data set were excluded from the analyses. The HERMES-24 score was calculated as the sum of the patient's age/10 and NIH Stroke Scale (NIHSS) score at 24 hours after randomization. The predictive ability of the score for a 90-day outcome (modified Rankin Scale [mRS] scores ≤2 and ≤3, ordinal mRS score, and mortality) was investigated.ResultsAmong 435 patients (48.5% men, median age 71 years), the median onset-to-randomization time was 654 (interquartile range 516-849) minutes and the median baseline NIHSS score was 16 (interquartile range 13-21). The HERMES-24 score was predictive of 90-day mRS scores ≤2 and ≤3, ordinal mRS score, and mortality in both the EVT arm (n = 223, c-statistic [95% CI] 0.917 [0.875-0.944], 0.895 [0.853-0.938], 0.820 [0.745-0.891], and 0.849 [0.776-0.922], respectively) and the control arm (n = 212, c-statistic [95% CI] 0.921 [0.872-0.969], 0.879 [0.827-0.930], 0.805 [0.746-0.852], and 0.805 [0.738-0.871], respectively).DiscussionThe HERMES-24 score was highly predictive of 90-day outcome among patients with stroke due to LVO and small ischemic core for those presenting in the late time window, irrespective of intervention. This score must be further validated in a real-world clinical setting if it is applicable to all patients with LVO admitted in late time windows.
UR - https://www.scopus.com/pages/publications/105010062820
U2 - 10.1212/WNL.0000000000213796
DO - 10.1212/WNL.0000000000213796
M3 - Article
C2 - 40609063
AN - SCOPUS:105010062820
SN - 0028-3878
VL - 105
JO - Neurology
JF - Neurology
IS - 3
ER -