Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy

Suresh K. Pandey; Yihui Chen; Robert H. Zawada; Allan Oseroff; Ravindra K. Pandey

doi:10.1117/12.647866

Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy

Suresh K. Pandey
, Yihui Chen
, Robert H. Zawada
, Allan Oseroff
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

Roswell Park Cancer Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

HPPH (a chlorophyll-a analog) was linked with a cyanine dye and the resulting conjugate was found to be an efficient tumor imaging (fluorescence imaging) and photosensitizing agent (PDT). Our preliminary results suggest that tumor-avid porphyrin-based compounds can be used as vehicles for delivering the desired fluorophores to tumor for fluorescence imaging. In an early diagnosis of microscopic lesions in pre-clinical studies (C3H mice implanted with RIF tumors) the HPPH-cyanine dye conjugate showed tumor-imaging capability (λ _ex: 780 nm, λ _em: 860 nm) at the non- therapeutic doses that are 100 fold lower than those used therapeutically. Compared to the cyanine dye, the corresponding HPPH-conjugate showed enhanced long-term tumor imaging ability.

Original language	English
Title of host publication	Optical Methods for Tumor Treatment and Detection
Subtitle of host publication	Mechanisms and Techniques in Photodynamic Therapy XV
DOIs	https://doi.org/10.1117/12.647866
State	Published - 2006
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV - San Jose, CA, United States Duration: Jan 21 2006 → Jan 22 2006

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6139
ISSN (Print)	1605-7422

Conference

Conference	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV
Country/Territory	United States
City	San Jose, CA
Period	01/21/06 → 01/22/06

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10.1117/12.647866

Cite this

Pandey, S. K., Chen, Y., Zawada, R. H., Oseroff, A., & Pandey, R. K. (2006). Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV Article 613905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6139). https://doi.org/10.1117/12.647866

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title = "Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy",

abstract = "HPPH (a chlorophyll-a analog) was linked with a cyanine dye and the resulting conjugate was found to be an efficient tumor imaging (fluorescence imaging) and photosensitizing agent (PDT). Our preliminary results suggest that tumor-avid porphyrin-based compounds can be used as vehicles for delivering the desired fluorophores to tumor for fluorescence imaging. In an early diagnosis of microscopic lesions in pre-clinical studies (C3H mice implanted with RIF tumors) the HPPH-cyanine dye conjugate showed tumor-imaging capability (λ ex: 780 nm, λ em: 860 nm) at the non- therapeutic doses that are 100 fold lower than those used therapeutically. Compared to the cyanine dye, the corresponding HPPH-conjugate showed enhanced long-term tumor imaging ability.",

author = "Pandey, \{Suresh K.\} and Yihui Chen and Zawada, \{Robert H.\} and Allan Oseroff and Pandey, \{Ravindra K.\}",

year = "2006",

doi = "10.1117/12.647866",

language = "English",

isbn = "0819461822",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Optical Methods for Tumor Treatment and Detection",

note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV ; Conference date: 21-01-2006 Through 22-01-2006",

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Pandey, SK, Chen, Y, Zawada, RH, Oseroff, A & Pandey, RK 2006, Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy. in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV., 613905, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, San Jose, CA, United States, 01/21/06. https://doi.org/10.1117/12.647866

Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy. / Pandey, Suresh K.; Chen, Yihui; Zawada, Robert H. et al.
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV. 2006. 613905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6139).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy

AU - Pandey, Suresh K.

AU - Chen, Yihui

AU - Zawada, Robert H.

AU - Oseroff, Allan

AU - Pandey, Ravindra K.

PY - 2006

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N2 - HPPH (a chlorophyll-a analog) was linked with a cyanine dye and the resulting conjugate was found to be an efficient tumor imaging (fluorescence imaging) and photosensitizing agent (PDT). Our preliminary results suggest that tumor-avid porphyrin-based compounds can be used as vehicles for delivering the desired fluorophores to tumor for fluorescence imaging. In an early diagnosis of microscopic lesions in pre-clinical studies (C3H mice implanted with RIF tumors) the HPPH-cyanine dye conjugate showed tumor-imaging capability (λ ex: 780 nm, λ em: 860 nm) at the non- therapeutic doses that are 100 fold lower than those used therapeutically. Compared to the cyanine dye, the corresponding HPPH-conjugate showed enhanced long-term tumor imaging ability.

AB - HPPH (a chlorophyll-a analog) was linked with a cyanine dye and the resulting conjugate was found to be an efficient tumor imaging (fluorescence imaging) and photosensitizing agent (PDT). Our preliminary results suggest that tumor-avid porphyrin-based compounds can be used as vehicles for delivering the desired fluorophores to tumor for fluorescence imaging. In an early diagnosis of microscopic lesions in pre-clinical studies (C3H mice implanted with RIF tumors) the HPPH-cyanine dye conjugate showed tumor-imaging capability (λ ex: 780 nm, λ em: 860 nm) at the non- therapeutic doses that are 100 fold lower than those used therapeutically. Compared to the cyanine dye, the corresponding HPPH-conjugate showed enhanced long-term tumor imaging ability.

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M3 - Conference contribution

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SN - 0819461822

SN - 9780819461827

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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T2 - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV

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ER -

Pandey SK, Chen Y, Zawada RH, Oseroff A, Pandey RK. Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV. 2006. 613905. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.647866

Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy

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