Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis

Haeja Kessler; Kaiyu Jiang; James N. Jarvis

doi:10.3389/fimmu.2018.02964

Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis

Haeja Kessler
, Kaiyu Jiang
, James N. Jarvis

Pediatrics

SUNY Buffalo

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.

Original language	English
Article number	2964
Journal	Frontiers in Immunology
Volume	9
DOIs	https://doi.org/10.3389/fimmu.2018.02964
State	Published - Dec 14 2018

Keywords

enhancer
genetics
juvenile idiopathic arthritis (JIA)
non-coding genome
topically associated domains

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10.3389/fimmu.2018.02964

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title = "Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis",

abstract = "The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.",

keywords = "enhancer, genetics, juvenile idiopathic arthritis (JIA), non-coding genome, topically associated domains",

author = "Haeja Kessler and Kaiyu Jiang and Jarvis, \{James N.\}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2018 Kessler, Jiang and Jarvis.",

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AU - Kessler, Haeja

AU - Jiang, Kaiyu

AU - Jarvis, James N.

PY - 2018/12/14

Y1 - 2018/12/14

N2 - The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.

AB - The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.

KW - enhancer

KW - genetics

KW - juvenile idiopathic arthritis (JIA)

KW - non-coding genome

KW - topically associated domains

UR - https://www.scopus.com/pages/publications/85059925898

U2 - 10.3389/fimmu.2018.02964

DO - 10.3389/fimmu.2018.02964

M3 - Review article

C2 - 30619322

AN - SCOPUS:85059925898

SN - 1664-3224

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 2964

ER -

Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis

Abstract

Keywords

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