Abstract
Four-day-old rat pups that are raised artificially on a high-carbohydrate (HC) milk formula immediately develop hyperinsulinemia, which persists into adulthood without any further nutritional stimulus. cDNA array analysis was used to identify large-scale changes in gene expression patterns in islets from 12- and 100-day-old HC rats in response to the HC dietary modification during the suckling period. It was observed that the expression of several genes that belong to clusters involved in β-cell development and/or β-cell function was significantly upregulated in islets from 12- and 100-day-old HC rats. It is inferred that in addition to predicted changes in gene expression, for example pre-proinsulin gene, global changes in gene expression contribute to the hyperinsulinemic state in the HC rat.
| Original language | English |
|---|---|
| Pages (from-to) | 2053-2060 |
| Number of pages | 8 |
| Journal | Diabetes |
| Volume | 50 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2001 |
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