Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy

Maryann E. Mikucki; Joseph J. Skitzki; John G. Frelinger; Kunle Odunsi; Thomas F. Gajewski; Andrew D. Luster; Sharon S. Evans

doi:10.1080/2162402X.2015.1116675

Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy

Maryann E. Mikucki
, Joseph J. Skitzki
, John G. Frelinger
, Kunle Odunsi
, Thomas F. Gajewski
, Andrew D. Luster
, Sharon S. Evans

Roswell Park - Tumor Immunology

Roswell Park Cancer Institute
University of Rochester
The University of Chicago
Massachusetts General Hospital

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-regulator of cytotoxic CD8⁺ T cell extravasation and tumor control despite the multiplicity of chemokines available in the tumor landscape.

Original language	English
Article number	e1116675
Journal	OncoImmunology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1080/2162402X.2015.1116675
State	Published - May 3 2016

Keywords

Adoptive T cell transfer
Cancer immunotherapy
Chemokine receptor
CXCR3
T cell trafficking
Tumor vessels

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10.1080/2162402X.2015.1116675

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title = "Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy",

abstract = "Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-regulator of cytotoxic CD8+ T cell extravasation and tumor control despite the multiplicity of chemokines available in the tumor landscape.",

keywords = "Adoptive T cell transfer, Cancer immunotherapy, Chemokine receptor, CXCR3, T cell trafficking, Tumor vessels",

author = "Mikucki, \{Maryann E.\} and Skitzki, \{Joseph J.\} and Frelinger, \{John G.\} and Kunle Odunsi and Gajewski, \{Thomas F.\} and Luster, \{Andrew D.\} and Evans, \{Sharon S.\}",

note = "Publisher Copyright: {\textcopyright} Maryann E. Mikucki, Joseph J. Skitzki, John G. Frelinger, Kunle Odunsi, Thomas F. Gajewski, Andrew D. Luster, and Sharon S. Evans.",

year = "2016",

month = may,

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doi = "10.1080/2162402X.2015.1116675",

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T1 - Unlocking tumor vascular barriers with CXCR3

T2 - Implications for cancer immunotherapy

AU - Mikucki, Maryann E.

AU - Skitzki, Joseph J.

AU - Frelinger, John G.

AU - Odunsi, Kunle

AU - Gajewski, Thomas F.

AU - Luster, Andrew D.

AU - Evans, Sharon S.

N1 - Publisher Copyright: © Maryann E. Mikucki, Joseph J. Skitzki, John G. Frelinger, Kunle Odunsi, Thomas F. Gajewski, Andrew D. Luster, and Sharon S. Evans.

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-regulator of cytotoxic CD8+ T cell extravasation and tumor control despite the multiplicity of chemokines available in the tumor landscape.

AB - Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-regulator of cytotoxic CD8+ T cell extravasation and tumor control despite the multiplicity of chemokines available in the tumor landscape.

KW - Adoptive T cell transfer

KW - Cancer immunotherapy

KW - Chemokine receptor

KW - CXCR3

KW - T cell trafficking

KW - Tumor vessels

UR - https://www.scopus.com/pages/publications/84964653325

U2 - 10.1080/2162402X.2015.1116675

DO - 10.1080/2162402X.2015.1116675

M3 - Article

AN - SCOPUS:84964653325

SN - 2162-4011

VL - 5

JO - OncoImmunology

JF - OncoImmunology

IS - 5

M1 - e1116675

ER -

Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy

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Keywords

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