Ultrasensitive Detection of Cu2+ Using a Microcantilever Sensor Modified with L-Cysteine Self-Assembled Monolayer

Xiaohe Xu; Na Zhang; Gilbert M. Brown; Thomas G. Thundat; Hai Feng Ji

doi:10.1007/s12010-017-2511-7

Ultrasensitive Detection of Cu²⁺ Using a Microcantilever Sensor Modified with L-Cysteine Self-Assembled Monolayer

Xiaohe Xu
, Na Zhang
, Gilbert M. Brown
, Thomas G. Thundat
, Hai Feng Ji

Department of Chemical and Biological Engineering

Drexel University
Oak Ridge National Laboratory

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A microcantilever was modified with a self-assembled monolayer (SAM) of L-cysteine for the sensitively and selectively response to Cu(II) ions in aqueous solution. The microcantilever undergoes bending due to sorption of Cu(II) ions. The interaction of Cu(II) ions with the L-cysteine on the cantilever is diffusion controlled and does not follow a simple Langmuir adsorption model. A concentration of 10⁻¹⁰ M Cu(II) was detected in a fluid cell using this technology. Other cations, such as Ni²⁺, Zn²⁺, Pb²⁺, Cd²⁺, Ca²⁺, K⁺, and Na⁺, did not respond with a significant deflection, indicating that this L-cysteine-modified cantilever responded selectively and sensitively to Cu(II).

Original language	English
Pages (from-to)	555-565
Number of pages	11
Journal	Applied Biochemistry and Biotechnology
Volume	183
Issue number	2
DOIs	https://doi.org/10.1007/s12010-017-2511-7
State	Published - Oct 1 2017

Keywords

Adsorption-induced stress
And L-cysteine
Chemically modified surfaces
Cu detection
Microcantilevers
Self-assembled monolayers (SAM)

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10.1007/s12010-017-2511-7

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title = "Ultrasensitive Detection of Cu2+ Using a Microcantilever Sensor Modified with L-Cysteine Self-Assembled Monolayer",

abstract = "A microcantilever was modified with a self-assembled monolayer (SAM) of L-cysteine for the sensitively and selectively response to Cu(II) ions in aqueous solution. The microcantilever undergoes bending due to sorption of Cu(II) ions. The interaction of Cu(II) ions with the L-cysteine on the cantilever is diffusion controlled and does not follow a simple Langmuir adsorption model. A concentration of 10−10 M Cu(II) was detected in a fluid cell using this technology. Other cations, such as Ni2+, Zn2+, Pb2+, Cd2+, Ca2+, K+, and Na+, did not respond with a significant deflection, indicating that this L-cysteine-modified cantilever responded selectively and sensitively to Cu(II).",

keywords = "Adsorption-induced stress, And L-cysteine, Chemically modified surfaces, Cu detection, Microcantilevers, Self-assembled monolayers (SAM)",

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AU - Xu, Xiaohe

AU - Zhang, Na

AU - Brown, Gilbert M.

AU - Thundat, Thomas G.

AU - Ji, Hai Feng

PY - 2017/10/1

Y1 - 2017/10/1

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AB - A microcantilever was modified with a self-assembled monolayer (SAM) of L-cysteine for the sensitively and selectively response to Cu(II) ions in aqueous solution. The microcantilever undergoes bending due to sorption of Cu(II) ions. The interaction of Cu(II) ions with the L-cysteine on the cantilever is diffusion controlled and does not follow a simple Langmuir adsorption model. A concentration of 10−10 M Cu(II) was detected in a fluid cell using this technology. Other cations, such as Ni2+, Zn2+, Pb2+, Cd2+, Ca2+, K+, and Na+, did not respond with a significant deflection, indicating that this L-cysteine-modified cantilever responded selectively and sensitively to Cu(II).

KW - Adsorption-induced stress

KW - And L-cysteine

KW - Chemically modified surfaces

KW - Cu detection

KW - Microcantilevers

KW - Self-assembled monolayers (SAM)

UR - https://www.scopus.com/pages/publications/85019611666

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SN - 0273-2289

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JF - Applied Biochemistry and Biotechnology

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ER -

Ultrasensitive Detection of Cu²⁺ Using a Microcantilever Sensor Modified with L-Cysteine Self-Assembled Monolayer

Abstract

Keywords

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