Tunicamycin enhances the antiviral and anticellular activity of interferon

R. K. Maheshwari; T. Sreevalsan; R. H. Silverman; J. Hay; R. M. Friedman

doi:10.1126/science.6187067

Tunicamycin enhances the antiviral and anticellular activity of interferon

R. K. Maheshwari
, T. Sreevalsan
, R. H. Silverman
, J. Hay
, R. M. Friedman

Microbiology and Immunology

Uniformed Services University of the Health Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.

Original language	English
Pages (from-to)	1339-1341
Number of pages	3
Journal	Science
Volume	219
Issue number	4590
DOIs	https://doi.org/10.1126/science.6187067
State	Published - 1983

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title = "Tunicamycin enhances the antiviral and anticellular activity of interferon",

abstract = "The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.",

author = "Maheshwari, \{R. K.\} and T. Sreevalsan and Silverman, \{R. H.\} and J. Hay and Friedman, \{R. M.\}",

year = "1983",

doi = "10.1126/science.6187067",

language = "English",

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pages = "1339--1341",

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TY - JOUR

T1 - Tunicamycin enhances the antiviral and anticellular activity of interferon

AU - Maheshwari, R. K.

AU - Sreevalsan, T.

AU - Silverman, R. H.

AU - Hay, J.

AU - Friedman, R. M.

PY - 1983

Y1 - 1983

N2 - The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.

AB - The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.

UR - https://www.scopus.com/pages/publications/0020622127

U2 - 10.1126/science.6187067

DO - 10.1126/science.6187067

M3 - Article

C2 - 6187067

AN - SCOPUS:0020622127

SN - 0036-8075

VL - 219

SP - 1339

EP - 1341

JO - Science

JF - Science

IS - 4590

ER -

Tunicamycin enhances the antiviral and anticellular activity of interferon

Abstract

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