Tumor immunolocalization using 124I-iodine-labeled JAA-F11 antibody to Thomsen-Friedenreich alpha-linked antigen

Richa Chaturvedi; Jamie Heimburg; Jun Yan; Stephen Koury; Munawwar Sajjad; Hani H. Abdel-Nabi; Kate Rittenhouse-Olson

doi:10.1016/j.apradiso.2007.07.029

Tumor immunolocalization using ¹²⁴I-iodine-labeled JAA-F11 antibody to Thomsen-Friedenreich alpha-linked antigen

Richa Chaturvedi
, Jamie Heimburg
, Jun Yan
, Stephen Koury
, Munawwar Sajjad
, Hani H. Abdel-Nabi
, Kate Rittenhouse-Olson

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Clinical immunolocalization has been attempted by others with an anti-Thomsen-Friedenreich antigen (TF-Ag) mAb that bound both alpha- and beta-linked TF-Ag. In this report, ¹²⁴I-labeled mAb JAA-F11 specific for alpha-linked TF-Ag showed higher tumor specificity in in vivo micro-positron emission tomography (micro-PET) of the mouse mammary adenocarcinoma line, 4T1, showing no preferential uptake by the kidney. Labeled product remained localized in the tumor for at least 20 days. Glycan array analysis showed structural specificity of the antibody.

Original language	English
Pages (from-to)	278-287
Number of pages	10
Journal	Applied Radiation and Isotopes
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/j.apradiso.2007.07.029
State	Published - Mar 2008

Keywords

Biodistribution
Breast carcinoma
Immunolocalization
JAA-F11
Micro-PET
Radiolabeled monoclonal antibody
TF-Ag

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10.1016/j.apradiso.2007.07.029

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title = "Tumor immunolocalization using 124I-iodine-labeled JAA-F11 antibody to Thomsen-Friedenreich alpha-linked antigen",

abstract = "Clinical immunolocalization has been attempted by others with an anti-Thomsen-Friedenreich antigen (TF-Ag) mAb that bound both alpha- and beta-linked TF-Ag. In this report, 124I-labeled mAb JAA-F11 specific for alpha-linked TF-Ag showed higher tumor specificity in in vivo micro-positron emission tomography (micro-PET) of the mouse mammary adenocarcinoma line, 4T1, showing no preferential uptake by the kidney. Labeled product remained localized in the tumor for at least 20 days. Glycan array analysis showed structural specificity of the antibody.",

keywords = "Biodistribution, Breast carcinoma, Immunolocalization, JAA-F11, Micro-PET, Radiolabeled monoclonal antibody, TF-Ag",

author = "Richa Chaturvedi and Jamie Heimburg and Jun Yan and Stephen Koury and Munawwar Sajjad and Abdel-Nabi, \{Hani H.\} and Kate Rittenhouse-Olson",

year = "2008",

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doi = "10.1016/j.apradiso.2007.07.029",

language = "English",

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AU - Chaturvedi, Richa

AU - Heimburg, Jamie

AU - Yan, Jun

AU - Koury, Stephen

AU - Sajjad, Munawwar

AU - Abdel-Nabi, Hani H.

AU - Rittenhouse-Olson, Kate

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AB - Clinical immunolocalization has been attempted by others with an anti-Thomsen-Friedenreich antigen (TF-Ag) mAb that bound both alpha- and beta-linked TF-Ag. In this report, 124I-labeled mAb JAA-F11 specific for alpha-linked TF-Ag showed higher tumor specificity in in vivo micro-positron emission tomography (micro-PET) of the mouse mammary adenocarcinoma line, 4T1, showing no preferential uptake by the kidney. Labeled product remained localized in the tumor for at least 20 days. Glycan array analysis showed structural specificity of the antibody.

KW - Biodistribution

KW - Breast carcinoma

KW - Immunolocalization

KW - JAA-F11

KW - Micro-PET

KW - Radiolabeled monoclonal antibody

KW - TF-Ag

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DO - 10.1016/j.apradiso.2007.07.029

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SN - 0969-8043

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JF - Applied Radiation and Isotopes

IS - 3

ER -

Tumor immunolocalization using ¹²⁴I-iodine-labeled JAA-F11 antibody to Thomsen-Friedenreich alpha-linked antigen

Abstract

Keywords

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