Abstract
Many attempts have been made to inhibit viral and neoplastic diseases by targeting the RNA system. The pathophysiologic significance of the microRNA system and the therapeutic potential of its manipulation are discussed. Studies of double-stranded RNA derivatives are reviewed. The therapeutic potential of one of these compounds, polyI:MPC, is emphasized. Studies of other related antiviral and antineoplastic agents are discussed, including 2′-deoxyoligocytidilates and telomerase inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 1283-1286 |
| Number of pages | 4 |
| Journal | Experimental Biology and Medicine |
| Volume | 231 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2006 |
Keywords
- 2′-deoxyoligocytidilates
- AIDS
- Double-stranded and single-stranded RNA
- HIV infection
- Neoplastic diseases
- Telomerase inhibitors
- Thiolated polyi:polyC (pl:MPC)
- Viral diseases
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