Trace amines and cocaine abuse

Jun Xu Li

doi:10.1021/cn500104s

Trace amines and cocaine abuse

Jun Xu Li

Pharmacology and Toxicology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Cocaine addiction remains a clinical challenge with no effective pharmacotherapy available. Trace amine associated receptor (TAAR) 1 represents a promising drug target for the modulation of dopaminergic system and stimulant abuse. This Viewpoint discusses the emerging data which strongly suggest that TAAR 1 functions as a molecular "brake" that controls the addiction-related effects of cocaine and could be a novel drug target for the development of efficacious pharmacotherapy to treat cocaine addiction.

Original language	English
Pages (from-to)	497-498
Number of pages	2
Journal	ACS Chemical Neuroscience
Volume	5
Issue number	7
DOIs	https://doi.org/10.1021/cn500104s
State	Published - Jul 16 2014

Keywords

Trace amine associated receptor 1
cocaine addiction
drug target
preclinical

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10.1021/cn500104s

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title = "Trace amines and cocaine abuse",

abstract = "Cocaine addiction remains a clinical challenge with no effective pharmacotherapy available. Trace amine associated receptor (TAAR) 1 represents a promising drug target for the modulation of dopaminergic system and stimulant abuse. This Viewpoint discusses the emerging data which strongly suggest that TAAR 1 functions as a molecular {"}brake{"} that controls the addiction-related effects of cocaine and could be a novel drug target for the development of efficacious pharmacotherapy to treat cocaine addiction.",

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AB - Cocaine addiction remains a clinical challenge with no effective pharmacotherapy available. Trace amine associated receptor (TAAR) 1 represents a promising drug target for the modulation of dopaminergic system and stimulant abuse. This Viewpoint discusses the emerging data which strongly suggest that TAAR 1 functions as a molecular "brake" that controls the addiction-related effects of cocaine and could be a novel drug target for the development of efficacious pharmacotherapy to treat cocaine addiction.

KW - Trace amine associated receptor 1

KW - cocaine addiction

KW - drug target

KW - preclinical

UR - https://www.scopus.com/pages/publications/84904444409

U2 - 10.1021/cn500104s

DO - 10.1021/cn500104s

M3 - Review article

C2 - 24849494

AN - SCOPUS:84904444409

SN - 1948-7193

VL - 5

SP - 497

EP - 498

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

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ER -

Trace amines and cocaine abuse

Abstract

Keywords

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