Toward magnetic resonance fingerprinting for low-field MR-guided radiation therapy

Purpose: The acquisition of multiparametric quantitative magnetic resonance imaging (qMRI) is becoming increasingly important for functional characterization of cancer prior to- and throughout the course of radiation therapy. The feasibility of a qMRI method known as magnetic resonance fingerprinting (MRF) for rapid T₁ and T₂ mapping was assessed on a low-field MR-linac system. Methods: A three-dimensional MRF sequence was implemented on a 0.35T MR-guided radiotherapy system. MRF-derived measurements of T₁ and T₂ were compared to those obtained with gold standard single spin echo methods, and the impacts of the radiofrequency field homogeneity and scan times ranging between 6 and 48 min were analyzed by acquiring between 1 and 8 spokes per time point in a standard quantitative system phantom. The short-term repeatability of MRF was assessed over three measurements taken over a 10-h period. To evaluate transferability, MRF measurements were acquired on two additional MR-guided radiotherapy systems. Preliminary human volunteer studies were performed. Results: The phantom benchmarking studies showed that MRF is capable of mapping T₁ and T₂ values within 8% and 10% of gold standard measures, respectively, at 0.35T. The coefficient of variation of T₁ and T₂ estimates over three repeated scans was < 5% over a broad range of relaxation times. The T₁ and T₂ times derived using a single-spoke MRF acquisition across three scanners were near unity and mean percent errors in T₁ and T₂ estimates using the same phantom were < 3%. The mean percent differences in T₁ and T₂ as a result of truncating the scan time to 6 min over the large range of relaxation times in the system phantom were 0.65% and 4.05%, respectively. Conclusions: The technical feasibility and accuracy of MRF on a low-field MR-guided radiation therapy device has been demonstrated. MRF can be used to measure accurate T₁ and T₂ maps in three dimensions from a brief 6-min scan, offering strong potential for efficient and reproducible qMRI for future clinical trials in functional plan adaptation and tumor/normal tissue response assessment.