Total synthesis of a sialylated and sulfated oligosaccharide from O- linked glycoproteins

Jie Xia; Conrad F. Piskorz; James L. Alderfer; Robert D. Locke; Khushi L. Matta

doi:10.1016/S0040-4039(00)00261-6

Total synthesis of a sialylated and sulfated oligosaccharide from O- linked glycoproteins

Jie Xia
, Conrad F. Piskorz
, James L. Alderfer
, Robert D. Locke
, Khushi L. Matta

Department of Chemical and Biological Engineering

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The total synthesis of a sialylated and sulfated oligosaccharide 1 representative of a structure occurring in respiratory mucins has been accomplished. Our strategy depends upon the employment of 2-naphthymethyl (NAP) protection for hydroxyl functions. Choice of the well-defined sialyl donor 15 was made because of its enhanced reactivity over the parent compound 14 for glycosylation. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2773-2776
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	16
DOIs	https://doi.org/10.1016/S0040-4039(00)00261-6
State	Published - Apr 15 2000

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title = "Total synthesis of a sialylated and sulfated oligosaccharide from O- linked glycoproteins",

abstract = "The total synthesis of a sialylated and sulfated oligosaccharide 1 representative of a structure occurring in respiratory mucins has been accomplished. Our strategy depends upon the employment of 2-naphthymethyl (NAP) protection for hydroxyl functions. Choice of the well-defined sialyl donor 15 was made because of its enhanced reactivity over the parent compound 14 for glycosylation. (C) 2000 Elsevier Science Ltd.",

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T1 - Total synthesis of a sialylated and sulfated oligosaccharide from O- linked glycoproteins

AU - Xia, Jie

AU - Piskorz, Conrad F.

AU - Alderfer, James L.

AU - Locke, Robert D.

AU - Matta, Khushi L.

PY - 2000/4/15

Y1 - 2000/4/15

N2 - The total synthesis of a sialylated and sulfated oligosaccharide 1 representative of a structure occurring in respiratory mucins has been accomplished. Our strategy depends upon the employment of 2-naphthymethyl (NAP) protection for hydroxyl functions. Choice of the well-defined sialyl donor 15 was made because of its enhanced reactivity over the parent compound 14 for glycosylation. (C) 2000 Elsevier Science Ltd.

AB - The total synthesis of a sialylated and sulfated oligosaccharide 1 representative of a structure occurring in respiratory mucins has been accomplished. Our strategy depends upon the employment of 2-naphthymethyl (NAP) protection for hydroxyl functions. Choice of the well-defined sialyl donor 15 was made because of its enhanced reactivity over the parent compound 14 for glycosylation. (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034655842

U2 - 10.1016/S0040-4039(00)00261-6

DO - 10.1016/S0040-4039(00)00261-6

M3 - Article

AN - SCOPUS:0034655842

SN - 0040-4039

VL - 41

SP - 2773

EP - 2776

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 16

ER -

Total synthesis of a sialylated and sulfated oligosaccharide from O- linked glycoproteins

Abstract

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