Tissue Persistence of Gentamicin in Man

Jerome J. Schentag; William J. Jusko; Martin E. Plaut; Thomas J. Cumbo; John W. Vance; Elias Abrutyn

doi:10.1001/jama.1977.03280040047019

Tissue Persistence of Gentamicin in Man

Jerome J. Schentag
, William J. Jusko
, Martin E. Plaut
, Thomas J. Cumbo
, John W. Vance
, Elias Abrutyn

SUNY Buffalo
Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

A two-compartment pharmacokinetic model was used to characterize serum concentrations and to predict tissue accumulation of gentamicin in 47 treated patients. Postmortem tissues were obtained in six cases; in each instance, tissues yielded the predicted amount of drug. Slow release of tissue-bound gentamicin accounts for its prolonged retention in the body. The two-compartment model adequately predicts gentamicin accumulation from serum concentrations and explains why this antibiotic persists in serum and urine.

Original language	English
Pages (from-to)	327-329
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	238
Issue number	4
DOIs	https://doi.org/10.1001/jama.1977.03280040047019
State	Published - Jul 25 1977

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abstract = "A two-compartment pharmacokinetic model was used to characterize serum concentrations and to predict tissue accumulation of gentamicin in 47 treated patients. Postmortem tissues were obtained in six cases; in each instance, tissues yielded the predicted amount of drug. Slow release of tissue-bound gentamicin accounts for its prolonged retention in the body. The two-compartment model adequately predicts gentamicin accumulation from serum concentrations and explains why this antibiotic persists in serum and urine.",

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AU - Vance, John W.

AU - Abrutyn, Elias

PY - 1977/7/25

Y1 - 1977/7/25

N2 - A two-compartment pharmacokinetic model was used to characterize serum concentrations and to predict tissue accumulation of gentamicin in 47 treated patients. Postmortem tissues were obtained in six cases; in each instance, tissues yielded the predicted amount of drug. Slow release of tissue-bound gentamicin accounts for its prolonged retention in the body. The two-compartment model adequately predicts gentamicin accumulation from serum concentrations and explains why this antibiotic persists in serum and urine.

AB - A two-compartment pharmacokinetic model was used to characterize serum concentrations and to predict tissue accumulation of gentamicin in 47 treated patients. Postmortem tissues were obtained in six cases; in each instance, tissues yielded the predicted amount of drug. Slow release of tissue-bound gentamicin accounts for its prolonged retention in the body. The two-compartment model adequately predicts gentamicin accumulation from serum concentrations and explains why this antibiotic persists in serum and urine.

UR - https://www.scopus.com/pages/publications/0017397369

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AN - SCOPUS:0017397369

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JF - JAMA: The Journal of the American Medical Association

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Tissue Persistence of Gentamicin in Man

Abstract

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