Thromboxane A2 analogue (U-46619) stimulates vascular PGI2 synthesis

Jamie Y. Jeremy; Dimitri P. Mikhailidis; Paresh Dandona

doi:10.1016/0014-2999(85)90066-4

Thromboxane A₂ analogue (U-46619) stimulates vascular PGI₂ synthesis

Jamie Y. Jeremy
, Dimitri P. Mikhailidis
, Paresh Dandona

Medicine

Royal Free London NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Since platelet release reaction products (e.g. serotonin, ADP) stimulate prostacyclin (PGI₂) release in vitrom, we have investigated whether thromboxane A₂ (TXA₂) also has a similar effect. An analogue, U-46619, was used for the experiments, since TXA₂ is extremely unstable. U-46619 stimulated rat aortic PGI₂ release; this stimulation was abolished by (a) EDTA and (b) verapamil. We conclude that TXA₂ is a calcium-dependent stimulator of PGI₂ release; this property may be relevant to the limitation of platelet aggregates in vivo and to vascular injury.

Original language	English
Pages (from-to)	259-262
Number of pages	4
Journal	European Journal of Pharmacology
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(85)90066-4
State	Published - Jan 2 1985

Keywords

Prostacyclin
Thromboxane A
U-46619
Verapamil

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10.1016/0014-2999(85)90066-4

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title = "Thromboxane A2 analogue (U-46619) stimulates vascular PGI2 synthesis",

abstract = "Since platelet release reaction products (e.g. serotonin, ADP) stimulate prostacyclin (PGI2) release in vitrom, we have investigated whether thromboxane A2 (TXA2) also has a similar effect. An analogue, U-46619, was used for the experiments, since TXA2 is extremely unstable. U-46619 stimulated rat aortic PGI2 release; this stimulation was abolished by (a) EDTA and (b) verapamil. We conclude that TXA2 is a calcium-dependent stimulator of PGI2 release; this property may be relevant to the limitation of platelet aggregates in vivo and to vascular injury.",

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AU - Jeremy, Jamie Y.

AU - Mikhailidis, Dimitri P.

AU - Dandona, Paresh

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Y1 - 1985/1/2

N2 - Since platelet release reaction products (e.g. serotonin, ADP) stimulate prostacyclin (PGI2) release in vitrom, we have investigated whether thromboxane A2 (TXA2) also has a similar effect. An analogue, U-46619, was used for the experiments, since TXA2 is extremely unstable. U-46619 stimulated rat aortic PGI2 release; this stimulation was abolished by (a) EDTA and (b) verapamil. We conclude that TXA2 is a calcium-dependent stimulator of PGI2 release; this property may be relevant to the limitation of platelet aggregates in vivo and to vascular injury.

AB - Since platelet release reaction products (e.g. serotonin, ADP) stimulate prostacyclin (PGI2) release in vitrom, we have investigated whether thromboxane A2 (TXA2) also has a similar effect. An analogue, U-46619, was used for the experiments, since TXA2 is extremely unstable. U-46619 stimulated rat aortic PGI2 release; this stimulation was abolished by (a) EDTA and (b) verapamil. We conclude that TXA2 is a calcium-dependent stimulator of PGI2 release; this property may be relevant to the limitation of platelet aggregates in vivo and to vascular injury.

KW - Prostacyclin

KW - Thromboxane A

KW - U-46619

KW - Verapamil

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JF - European Journal of Pharmacology

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ER -

Thromboxane A₂ analogue (U-46619) stimulates vascular PGI₂ synthesis

Abstract

Keywords

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