Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion

Shuen Shiuan Wang; Xuefeng Gao; Virginia del Solar; Xinheng Yu; Aristotelis Antonopoulos; Alan E. Friedman; Eryn K. Matich; G. Ekin Atilla-Gokcumen; Mehrab Nasirikenari; Joseph T. Lau; Anne Dell; Stuart M. Haslam; Roger A. Laine; Khushi L. Matta; Sriram Neelamegham

doi:10.1016/j.chembiol.2018.09.012

Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion

Shuen Shiuan Wang
, Xuefeng Gao
, Virginia del Solar
, Xinheng Yu
, Aristotelis Antonopoulos
, Alan E. Friedman
, Eryn K. Matich
, G. Ekin Atilla-Gokcumen
, Mehrab Nasirikenari
, Joseph T. Lau
, Anne Dell
, Stuart M. Haslam
, Roger A. Laine
, Khushi L. Matta
, Sriram Neelamegham

SUNY Buffalo
Tumor End LLC
Imperial College London
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Small-molecule inhibitors of glycosylation can be applied in basic science studies, and clinical investigations as anti-inflammatory, anti-metastatic, and anti-viral therapies. This article demonstrates that thioglycosides represent a class of potent metabolic decoys that resist hydrolysis, and block E-selectin-dependent leukocyte adhesion in models of inflammation.

Original language	English
Pages (from-to)	1519-1532.e5
Journal	Cell Chemical Biology
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.chembiol.2018.09.012
State	Published - Dec 20 2018

Keywords

N-glycan
decoy
fluid shear
glycosides
glycosylation
inflammation
leukocyte-endothelial adhesion
selectins
small-molecule inhibitors
thioglycoside

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10.1016/j.chembiol.2018.09.012

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Wang, S. S., Gao, X., Solar, V. D., Yu, X., Antonopoulos, A., Friedman, A. E., Matich, E. K., Atilla-Gokcumen, G. E., Nasirikenari, M., Lau, J. T., Dell, A., Haslam, S. M., Laine, R. A., Matta, K. L., & Neelamegham, S. (2018). Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion. Cell Chemical Biology, 25(12), 1519-1532.e5. https://doi.org/10.1016/j.chembiol.2018.09.012

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title = "Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion",

abstract = "Small-molecule inhibitors of glycosylation can be applied in basic science studies, and clinical investigations as anti-inflammatory, anti-metastatic, and anti-viral therapies. This article demonstrates that thioglycosides represent a class of potent metabolic decoys that resist hydrolysis, and block E-selectin-dependent leukocyte adhesion in models of inflammation.",

keywords = "N-glycan, decoy, fluid shear, glycosides, glycosylation, inflammation, leukocyte-endothelial adhesion, selectins, small-molecule inhibitors, thioglycoside",

author = "Wang, \{Shuen Shiuan\} and Xuefeng Gao and Solar, \{Virginia del\} and Xinheng Yu and Aristotelis Antonopoulos and Friedman, \{Alan E.\} and Matich, \{Eryn K.\} and Atilla-Gokcumen, \{G. Ekin\} and Mehrab Nasirikenari and Lau, \{Joseph T.\} and Anne Dell and Haslam, \{Stuart M.\} and Laine, \{Roger A.\} and Matta, \{Khushi L.\} and Sriram Neelamegham",

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month = dec,

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doi = "10.1016/j.chembiol.2018.09.012",

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Wang, SS, Gao, X, Solar, VD, Yu, X, Antonopoulos, A, Friedman, AE, Matich, EK, Atilla-Gokcumen, GE, Nasirikenari, M, Lau, JT, Dell, A, Haslam, SM, Laine, RA, Matta, KL & Neelamegham, S 2018, 'Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion', Cell Chemical Biology, vol. 25, no. 12, pp. 1519-1532.e5. https://doi.org/10.1016/j.chembiol.2018.09.012

TY - JOUR

T1 - Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion

AU - Wang, Shuen Shiuan

AU - Gao, Xuefeng

AU - Solar, Virginia del

AU - Yu, Xinheng

AU - Antonopoulos, Aristotelis

AU - Friedman, Alan E.

AU - Matich, Eryn K.

AU - Atilla-Gokcumen, G. Ekin

AU - Nasirikenari, Mehrab

AU - Lau, Joseph T.

AU - Dell, Anne

AU - Haslam, Stuart M.

AU - Laine, Roger A.

AU - Matta, Khushi L.

AU - Neelamegham, Sriram

PY - 2018/12/20

Y1 - 2018/12/20

N2 - Small-molecule inhibitors of glycosylation can be applied in basic science studies, and clinical investigations as anti-inflammatory, anti-metastatic, and anti-viral therapies. This article demonstrates that thioglycosides represent a class of potent metabolic decoys that resist hydrolysis, and block E-selectin-dependent leukocyte adhesion in models of inflammation.

AB - Small-molecule inhibitors of glycosylation can be applied in basic science studies, and clinical investigations as anti-inflammatory, anti-metastatic, and anti-viral therapies. This article demonstrates that thioglycosides represent a class of potent metabolic decoys that resist hydrolysis, and block E-selectin-dependent leukocyte adhesion in models of inflammation.

KW - N-glycan

KW - decoy

KW - fluid shear

KW - glycosides

KW - glycosylation

KW - inflammation

KW - leukocyte-endothelial adhesion

KW - selectins

KW - small-molecule inhibitors

KW - thioglycoside

UR - https://www.scopus.com/pages/publications/85055116750

U2 - 10.1016/j.chembiol.2018.09.012

DO - 10.1016/j.chembiol.2018.09.012

M3 - Article

C2 - 30344053

AN - SCOPUS:85055116750

SN - 2451-9456

VL - 25

SP - 1519-1532.e5

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 12

ER -

Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion

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