Theophylline-induced changes in the mouse brainstem auditory evoked potential

Because theophylline is a widely used analeptic, there is interest in its possible ototoxic and neurotoxic effects. The present study used the brainstem auditory evoked potential (BAEP) to evaluate the acute effects of theophylline on auditory electrophysiology in mice. Adult female C57BL/6 mice were injected intraperitoneally with 150 mg/kg theophylline or saline. The BAEP thresholds and latency-intensity profiles suggested that theophylline induced a rather slight but statistically significant change in auditory function that was suggestive of a temporary recruitment-type sensorineural deficit. This observation raises concerns about the possible ototoxic effects of theophylline, particularly in asthmatic patients and apneic preterm neonates who receive this drug chronically. While there was BAEP evidence of ototoxic effects for theophylline, there was no evidence of neurotoxic effects.