Theophylline disposition in residents living near a chemical waste site

Mary Linda Stotter Cuddy; Mark J. Gardner; Antoinette Mangione; Anthony M. Yurchak; Beverly Paigen; William J. Jusko

doi:10.1002/bdd.2510050406

Theophylline disposition in residents living near a chemical waste site

Mary Linda Stotter Cuddy
, Mark J. Gardner
, Antoinette Mangione
, Anthony M. Yurchak
, Beverly Paigen
, William J. Jusko

Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The pharmacokinetics of theophylline were compared in 11 residents living near a chemical waste site (Love Canal) and 25 control subjects from Western New York. Love Canal residents had documented chronic exposure to a variety of organic and halogenated compounds. Only young adults with no overt diseases were examined. Theophylline plasma clearances were similar in the two groups, although the enzyme inductive effects of tobacco smoking were further confirmed. The lack of environmental effect on theophylline clearance indicates that no chronic net change in one pathway of microsomal P‐448 oxidation occurred. The possibility of acute changes related to seasonal chemical exposure and mixed inductive/repressive effects from the myraid types of chemicals may confound the data.

Original language	English
Pages (from-to)	345-355
Number of pages	11
Journal	Biopharmaceutics and Drug Disposition
Volume	5
Issue number	4
DOIs	https://doi.org/10.1002/bdd.2510050406
State	Published - 1984

Keywords

Drug metabolites
Environmental pollution
Pharmacokinetics
Theophylline

Access to Document

10.1002/bdd.2510050406

Cite this

@article{a984e40b9a274e34951c9f29933c585c,

title = "Theophylline disposition in residents living near a chemical waste site",

abstract = "The pharmacokinetics of theophylline were compared in 11 residents living near a chemical waste site (Love Canal) and 25 control subjects from Western New York. Love Canal residents had documented chronic exposure to a variety of organic and halogenated compounds. Only young adults with no overt diseases were examined. Theophylline plasma clearances were similar in the two groups, although the enzyme inductive effects of tobacco smoking were further confirmed. The lack of environmental effect on theophylline clearance indicates that no chronic net change in one pathway of microsomal P‐448 oxidation occurred. The possibility of acute changes related to seasonal chemical exposure and mixed inductive/repressive effects from the myraid types of chemicals may confound the data.",

keywords = "Drug metabolites, Environmental pollution, Pharmacokinetics, Theophylline",

author = "Cuddy, \{Mary Linda Stotter\} and Gardner, \{Mark J.\} and Antoinette Mangione and Yurchak, \{Anthony M.\} and Beverly Paigen and Jusko, \{William J.\}",

year = "1984",

doi = "10.1002/bdd.2510050406",

language = "English",

volume = "5",

pages = "345--355",

journal = "Biopharmaceutics and Drug Disposition",

issn = "0142-2782",

publisher = "John Wiley and Sons Ltd",

number = "4",

}

TY - JOUR

T1 - Theophylline disposition in residents living near a chemical waste site

AU - Cuddy, Mary Linda Stotter

AU - Gardner, Mark J.

AU - Mangione, Antoinette

AU - Yurchak, Anthony M.

AU - Paigen, Beverly

AU - Jusko, William J.

PY - 1984

Y1 - 1984

N2 - The pharmacokinetics of theophylline were compared in 11 residents living near a chemical waste site (Love Canal) and 25 control subjects from Western New York. Love Canal residents had documented chronic exposure to a variety of organic and halogenated compounds. Only young adults with no overt diseases were examined. Theophylline plasma clearances were similar in the two groups, although the enzyme inductive effects of tobacco smoking were further confirmed. The lack of environmental effect on theophylline clearance indicates that no chronic net change in one pathway of microsomal P‐448 oxidation occurred. The possibility of acute changes related to seasonal chemical exposure and mixed inductive/repressive effects from the myraid types of chemicals may confound the data.

AB - The pharmacokinetics of theophylline were compared in 11 residents living near a chemical waste site (Love Canal) and 25 control subjects from Western New York. Love Canal residents had documented chronic exposure to a variety of organic and halogenated compounds. Only young adults with no overt diseases were examined. Theophylline plasma clearances were similar in the two groups, although the enzyme inductive effects of tobacco smoking were further confirmed. The lack of environmental effect on theophylline clearance indicates that no chronic net change in one pathway of microsomal P‐448 oxidation occurred. The possibility of acute changes related to seasonal chemical exposure and mixed inductive/repressive effects from the myraid types of chemicals may confound the data.

KW - Drug metabolites

KW - Environmental pollution

KW - Pharmacokinetics

KW - Theophylline

UR - https://www.scopus.com/pages/publications/0021742711

U2 - 10.1002/bdd.2510050406

DO - 10.1002/bdd.2510050406

M3 - Article

C2 - 6525442

AN - SCOPUS:0021742711

SN - 0142-2782

VL - 5

SP - 345

EP - 355

JO - Biopharmaceutics and Drug Disposition

JF - Biopharmaceutics and Drug Disposition

IS - 4

ER -

Theophylline disposition in residents living near a chemical waste site

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this