The utility of partial cross-over designs in early phase randomized prevention trials

Alan D. Hutson; Mary E. Reid

doi:10.1016/j.cct.2004.07.005

The utility of partial cross-over designs in early phase randomized prevention trials

Alan D. Hutson
, Mary E. Reid

Department of Biostatistics

Roswell Pk. Cancer Inst.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In this note, we outline the benefits of a partial cross-over design for a class of experiments where the interest is the cumulative effect of dose versus placebo. The goal of our design strategy is to answer several complex question efficiently in a phase II setting with a minimal number of assumptions with an eye towards planning a phase III study.

Original language	English
Pages (from-to)	493-501
Number of pages	9
Journal	Controlled Clinical Trials
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.cct.2004.07.005
State	Published - Oct 2004

Keywords

Clinical trial design
Cross-over design
Parallel design
Phase II study

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10.1016/j.cct.2004.07.005

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title = "The utility of partial cross-over designs in early phase randomized prevention trials",

abstract = "In this note, we outline the benefits of a partial cross-over design for a class of experiments where the interest is the cumulative effect of dose versus placebo. The goal of our design strategy is to answer several complex question efficiently in a phase II setting with a minimal number of assumptions with an eye towards planning a phase III study.",

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AB - In this note, we outline the benefits of a partial cross-over design for a class of experiments where the interest is the cumulative effect of dose versus placebo. The goal of our design strategy is to answer several complex question efficiently in a phase II setting with a minimal number of assumptions with an eye towards planning a phase III study.

KW - Clinical trial design

KW - Cross-over design

KW - Parallel design

KW - Phase II study

UR - https://www.scopus.com/pages/publications/4644298463

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DO - 10.1016/j.cct.2004.07.005

M3 - Article

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SP - 493

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JO - Controlled Clinical Trials

JF - Controlled Clinical Trials

IS - 5

ER -

The utility of partial cross-over designs in early phase randomized prevention trials

Abstract

Keywords

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