The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

Pui Chi Lo; M. Salomé Rodríguez-Morgade; Ravindra K. Pandey; Dennis K.P. Ng; Tomás Torres; Fabienne Dumoulin

doi:10.1039/c9cs00129h

The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

Pui Chi Lo
, M. Salomé Rodríguez-Morgade
, Ravindra K. Pandey
, Dennis K.P. Ng
, Tomás Torres
, Fabienne Dumoulin

Institute for Lasers Photonics and Biophotonics

City University of Hong Kong
Universidad Autónoma de Madrid
Chinese University of Hong Kong
Instituto IMDEA Nanociencia
Gebze Technical University

Research output: Contribution to journal › Review article › peer-review

698 Scopus citations

Abstract

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.

Original language	English
Pages (from-to)	1041-1056
Number of pages	16
Journal	Chemical Society Reviews
Volume	49
Issue number	4
DOIs	https://doi.org/10.1039/c9cs00129h
State	Published - Feb 21 2020

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title = "The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer",

abstract = "Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.",

author = "Lo, \{Pui Chi\} and Rodr{\'i}guez-Morgade, \{M. Salom{\'e}\} and Pandey, \{Ravindra K.\} and Ng, \{Dennis K.P.\} and Tom{\'a}s Torres and Fabienne Dumoulin",

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AU - Lo, Pui Chi

AU - Rodríguez-Morgade, M. Salomé

AU - Pandey, Ravindra K.

AU - Ng, Dennis K.P.

AU - Torres, Tomás

AU - Dumoulin, Fabienne

PY - 2020/2/21

Y1 - 2020/2/21

N2 - Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.

AB - Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.

UR - https://www.scopus.com/pages/publications/85079736454

U2 - 10.1039/c9cs00129h

DO - 10.1039/c9cs00129h

M3 - Review article

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SP - 1041

EP - 1056

JO - Chemical Society Reviews

JF - Chemical Society Reviews

IS - 4

ER -

The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

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