The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution

A. V. Fokin; P. V. Afonin; I. Yu Mikhailova; I. N. Tsygannik; T. Yu Mareeva; V. A. Nesmeyanov; W. Pangborn; N. Lee; W. Duax; E. Ciszak; V. Z. Pletnev

doi:10.1007/bf02758622

The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution

A. V. Fokin
, P. V. Afonin
, I. Yu Mikhailova
, I. N. Tsygannik
, T. Yu Mareeva
, V. A. Nesmeyanov
, W. Pangborn
, N. Lee
, W. Duax
, E. Ciszak
, V. Z. Pletnev

Department of Structural Biology

Russian Academy of Sciences
Hauptman Woodward Medical Institute
National Aeronautics and Space Administration

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 Å resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.

Original language	English
Pages (from-to)	512-519
Number of pages	8
Journal	Russian Journal of Bioorganic Chemistry
Volume	26
Issue number	9
DOIs	https://doi.org/10.1007/bf02758622
State	Published - Aug 2000

Keywords

Antigen-binding fragment
Interleukin-2
Monoclonal antibody
X-ray analysis

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10.1007/bf02758622

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Fokin, A. V., Afonin, P. V., Mikhailova, I. Y., Tsygannik, I. N., Mareeva, T. Y., Nesmeyanov, V. A., Pangborn, W., Lee, N., Duax, W., Ciszak, E., & Pletnev, V. Z. (2000). The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution. Russian Journal of Bioorganic Chemistry, 26(9), 512-519. https://doi.org/10.1007/bf02758622

@article{c07364fc9d1048c38c8e9fc07202d999,

title = "The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 {\AA} resolution",

abstract = "The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 {\AA} resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.",

keywords = "Antigen-binding fragment, Interleukin-2, Monoclonal antibody, X-ray analysis",

author = "Fokin, \{A. V.\} and Afonin, \{P. V.\} and Mikhailova, \{I. Yu\} and Tsygannik, \{I. N.\} and Mareeva, \{T. Yu\} and Nesmeyanov, \{V. A.\} and W. Pangborn and N. Lee and W. Duax and E. Ciszak and Pletnev, \{V. Z.\}",

year = "2000",

month = aug,

doi = "10.1007/bf02758622",

language = "English",

volume = "26",

pages = "512--519",

journal = "Russian Journal of Bioorganic Chemistry",

issn = "1068-1620",

publisher = "Pleiades Publishing",

number = "9",

}

Fokin, AV, Afonin, PV, Mikhailova, IY, Tsygannik, IN, Mareeva, TY, Nesmeyanov, VA, Pangborn, W, Lee, N, Duax, W, Ciszak, E & Pletnev, VZ 2000, 'The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution', Russian Journal of Bioorganic Chemistry, vol. 26, no. 9, pp. 512-519. https://doi.org/10.1007/bf02758622

TY - JOUR

T1 - The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution

AU - Fokin, A. V.

AU - Afonin, P. V.

AU - Mikhailova, I. Yu

AU - Tsygannik, I. N.

AU - Mareeva, T. Yu

AU - Nesmeyanov, V. A.

AU - Pangborn, W.

AU - Lee, N.

AU - Duax, W.

AU - Ciszak, E.

AU - Pletnev, V. Z.

PY - 2000/8

Y1 - 2000/8

N2 - The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 Å resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.

AB - The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 Å resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.

KW - Antigen-binding fragment

KW - Interleukin-2

KW - Monoclonal antibody

KW - X-ray analysis

UR - https://www.scopus.com/pages/publications/23044522855

U2 - 10.1007/bf02758622

DO - 10.1007/bf02758622

M3 - Article

AN - SCOPUS:23044522855

SN - 1068-1620

VL - 26

SP - 512

EP - 519

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

IS - 9

ER -

The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 in two crystal forms at 2.2 and 2.9 Å resolution

Abstract

Keywords

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