Abstract
OBJECTIVE: To introduce a method of chronic infusion of drugs into the cochlea using a osmotic pump. METHODS: A stainless steel tube was surgically implanted into the basal turn of the chinchilla cochlea and connected to the pump. To assess the reliability of the procedure, and the pump, Hank's solution or L-buthionine-[S,R]-sulfoximine (BSO) was infused into the cochlea by this pump and inferior colliculus (IC) potential and hair cell morphology were examined. RESULTS: In three Hank's solution infused cochleas, the thresholds of IC potential were kept in the normal level and no hair cell loss was found 14 days after the beginning of the infusion, suggested that the pump implantation and Hank's solution infusion had no significant effects on the cochlear functions. In contrast, threshold shifts of IC potentials and hair cell loss were found in two BSO infused animals, suggested that the infused solution had distributed into the whole cochlea. CONCLUSION: This study indicates that the osmotic pump can be used in chronic delivery of experimental drugs into the cochlea.
| Original language | English |
|---|---|
| Pages (from-to) | 169-171 |
| Number of pages | 3 |
| Journal | Zhonghua er bi yan hou ke za zhi |
| Volume | 33 |
| Issue number | 3 |
| State | Published - Jun 1998 |
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