TY - JOUR
T1 - The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial
T2 - Protocol for school-age follow-up
AU - Piper, Joseph D.
AU - Mazhanga, Clever
AU - Mwapaura, Marian
AU - Mapako, Gloria
AU - Mapurisa, Idah
AU - Mashedze, Tsitsi
AU - Munyama, Eunice
AU - Kuona, Maria
AU - Mashiri, Thombizodwa
AU - Sibanda, Kundai
AU - Matemavi, Dzidzai
AU - Tichagwa, Monica
AU - Nyoni, Soneni
AU - Saidi, Asinje
AU - Mangwende, Manasa
AU - Chidhanguro, Dzivaidzo
AU - Mpofu, Eddington
AU - Tome, Joice
AU - Mutasa, Batsirai
AU - Chasekwa, Bernard
AU - Smuk, Melanie
AU - Smith, Laura E.
AU - Njovo, Handrea
AU - Nyachowe, Chandiwana
AU - Muchekeza, Mary
AU - Mutasa, Kuda
AU - Sauramba, Virginia
AU - Langhaug, Lisa F.
AU - Tavengwa, Naume V.
AU - Gladstone, Melissa J.
AU - Wells, Jonathan C.
AU - Allen, Elizabeth
AU - Humphrey, Jean H.
AU - Ntozini, Robert
AU - Prendergast, Andrew J.
N1 - Publisher Copyright:
Copyright: © 2023 Piper JD et al.
PY - 2023
Y1 - 2023
N2 - Background: There is a need for follow-up of early-life stunting intervention trials into childhood to determine their long-term impact. A holistic school-age assessment of health, growth, physical and cognitive function will help to comprehensively characterise the sustained effects of early-life interventions. Methods: The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe assessed the effects of improved infant and young child feeding (IYCF) and/or improved water, sanitation and hygiene (WASH) on stunting and anaemia at 18 months. Among children enrolled to SHINE, 1,275 have been followed up at 7-8 years of age (1,000 children who have not been exposed to HIV, 268 exposed to HIV antenatally who remain HIV negative and 7 HIV positive children). Children were assessed using the School-Age Health, Activity, Resilience, Anthropometry and Neurocognitive (SAHARAN) toolbox, to measure their growth, body composition, cognitive and physical function. In parallel, a caregiver questionnaire assessed household demographics, socioeconomic status, adversity, nurturing, caregiver support, food and water insecurity. A monthly morbidity questionnaire is currently being administered by community health workers to evaluate school-age rates of infection and healthcare-seeking. The impact of the SHINE IYCF and WASH interventions, the early-life ‘exposome’, maternal HIV, and contemporary exposures on each school-age outcome will be assessed. We will also undertake an exploratory factor analysis to generate new, simpler metrics for assessment of cognition (COG-SAHARAN), growth (GROW-SAHARAN) and combined growth, cognitive and physical function (SUB-SAHARAN). The SUB-SAHARAN toolbox will be used to conduct annual assessments within the SHINE cohort from ages 8–12 years. Ethics and dissemination: Approval was obtained from Medical Research Council of Zimbabwe (08/02/21) and registered with Pan-African Clinical Trials Registry (PACTR202201828512110, 24/01/22). Primary caregivers provided written informed consent and children written assent. Findings will be disseminated through community sensitisation, peer-reviewed journals and stakeholders including the Zimbabwean Ministry of Health and Child Care.
AB - Background: There is a need for follow-up of early-life stunting intervention trials into childhood to determine their long-term impact. A holistic school-age assessment of health, growth, physical and cognitive function will help to comprehensively characterise the sustained effects of early-life interventions. Methods: The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe assessed the effects of improved infant and young child feeding (IYCF) and/or improved water, sanitation and hygiene (WASH) on stunting and anaemia at 18 months. Among children enrolled to SHINE, 1,275 have been followed up at 7-8 years of age (1,000 children who have not been exposed to HIV, 268 exposed to HIV antenatally who remain HIV negative and 7 HIV positive children). Children were assessed using the School-Age Health, Activity, Resilience, Anthropometry and Neurocognitive (SAHARAN) toolbox, to measure their growth, body composition, cognitive and physical function. In parallel, a caregiver questionnaire assessed household demographics, socioeconomic status, adversity, nurturing, caregiver support, food and water insecurity. A monthly morbidity questionnaire is currently being administered by community health workers to evaluate school-age rates of infection and healthcare-seeking. The impact of the SHINE IYCF and WASH interventions, the early-life ‘exposome’, maternal HIV, and contemporary exposures on each school-age outcome will be assessed. We will also undertake an exploratory factor analysis to generate new, simpler metrics for assessment of cognition (COG-SAHARAN), growth (GROW-SAHARAN) and combined growth, cognitive and physical function (SUB-SAHARAN). The SUB-SAHARAN toolbox will be used to conduct annual assessments within the SHINE cohort from ages 8–12 years. Ethics and dissemination: Approval was obtained from Medical Research Council of Zimbabwe (08/02/21) and registered with Pan-African Clinical Trials Registry (PACTR202201828512110, 24/01/22). Primary caregivers provided written informed consent and children written assent. Findings will be disseminated through community sensitisation, peer-reviewed journals and stakeholders including the Zimbabwean Ministry of Health and Child Care.
KW - body composition
KW - Child
KW - cognition
KW - fitness
KW - HIV
KW - IYCF
KW - nutrition
KW - WASH
UR - https://www.scopus.com/pages/publications/85178143190
U2 - 10.12688/wellcomeopenres.19463.1
DO - 10.12688/wellcomeopenres.19463.1
M3 - Article
AN - SCOPUS:85178143190
SN - 2398-502X
VL - 8
JO - Wellcome Open Research
JF - Wellcome Open Research
M1 - 306
ER -