The role of t cell receptor β chain genes in susceptibility to rheumatoid arthritis

Michael Mcdermott; Daniel L. Kastner; Christine Hsu; John D. Holloman; Gabriele Schmidt‐Wolf; Ante S. Lundberg; Animesh A. Sinha; Hugh O. Mcdevitt; Patrick Cashin; Michael G. Molloy; Brian Mulcahy; Fergal O'Gara; Fiona I. Mcconnell; Claire Adams; Muhammad A. Khan; Frederick Wolfe; Laurence A. Rubin; Daniel O. Clegg; Dee Husebye; Christopher I. Amos; Ryk H. Ward

doi:10.1002/art.1780380114

The role of t cell receptor β chain genes in susceptibility to rheumatoid arthritis

Michael Mcdermott
, Daniel L. Kastner
, Christine Hsu
, John D. Holloman
, Gabriele Schmidt‐Wolf
, Ante S. Lundberg
, Animesh A. Sinha
, Hugh O. Mcdevitt
, Patrick Cashin
, Michael G. Molloy
, Brian Mulcahy
, Fergal O'Gara
, Fiona I. Mcconnell
, Claire Adams
, Muhammad A. Khan
, Frederick Wolfe
, Laurence A. Rubin
, Daniel O. Clegg
, Dee Husebye
, Christopher I. Amos

Ryk H. Ward

Department of Dermatology

National Institutes of Health
Stanford University
University College Cork
Case Western Reserve University
University of Kansas
University of Toronto
University of Texas Health Science Center at Houston
University of Utah

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Objective. To evaluate the role of the T cell receptor β chain locus TCRB in genetic susceptibility to rheumatoid arthritis (RA). Methods. Twenty‐eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V _β6.7), a V _β12.2 SSCP marker, and a biallelic C_β restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity‐by‐descent in affected sib‐pairs. Results. Using the V _β12.2 marker, there was suggestive evidence of increased sib‐pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V _β6.7 and C_β yielded significance levels of 0.06 and 0.19, respectively. Conclusion. These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.

Original language	English
Pages (from-to)	91-95
Number of pages	5
Journal	Arthritis and Rheumatism
Volume	38
Issue number	1
DOIs	https://doi.org/10.1002/art.1780380114
State	Published - Jan 1995

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Mcdermott, M., Kastner, D. L., Hsu, C., Holloman, J. D., Schmidt‐Wolf, G., Lundberg, A. S., Sinha, A. A., Mcdevitt, H. O., Cashin, P., Molloy, M. G., Mulcahy, B., O'Gara, F., Mcconnell, F. I., Adams, C., Khan, M. A., Wolfe, F., Rubin, L. A., Clegg, D. O., Husebye, D., ... Ward, R. H. (1995). The role of t cell receptor β chain genes in susceptibility to rheumatoid arthritis. Arthritis and Rheumatism, 38(1), 91-95. https://doi.org/10.1002/art.1780380114

@article{a1351f6f80f241ababd36f852a796dfe,

title = "The role of t cell receptor β chain genes in susceptibility to rheumatoid arthritis",

abstract = "Objective. To evaluate the role of the T cell receptor β chain locus TCRB in genetic susceptibility to rheumatoid arthritis (RA). Methods. Twenty‐eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V β6.7), a V β12.2 SSCP marker, and a biallelic Cβ restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity‐by‐descent in affected sib‐pairs. Results. Using the V β12.2 marker, there was suggestive evidence of increased sib‐pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V β6.7 and Cβ yielded significance levels of 0.06 and 0.19, respectively. Conclusion. These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.",

author = "Michael Mcdermott and Kastner, \{Daniel L.\} and Christine Hsu and Holloman, \{John D.\} and Gabriele Schmidt‐Wolf and Lundberg, \{Ante S.\} and Sinha, \{Animesh A.\} and Mcdevitt, \{Hugh O.\} and Patrick Cashin and Molloy, \{Michael G.\} and Brian Mulcahy and Fergal O'Gara and Mcconnell, \{Fiona I.\} and Claire Adams and Khan, \{Muhammad A.\} and Frederick Wolfe and Rubin, \{Laurence A.\} and Clegg, \{Daniel O.\} and Dee Husebye and Amos, \{Christopher I.\} and Ward, \{Ryk H.\}",

year = "1995",

month = jan,

doi = "10.1002/art.1780380114",

language = "English",

volume = "38",

pages = "91--95",

journal = "Arthritis and Rheumatism",

issn = "0004-3591",

number = "1",

}

Mcdermott, M, Kastner, DL, Hsu, C, Holloman, JD, Schmidt‐Wolf, G, Lundberg, AS, Sinha, AA, Mcdevitt, HO, Cashin, P, Molloy, MG, Mulcahy, B, O'Gara, F, Mcconnell, FI, Adams, C, Khan, MA, Wolfe, F, Rubin, LA, Clegg, DO, Husebye, D, Amos, CI & Ward, RH 1995, 'The role of t cell receptor β chain genes in susceptibility to rheumatoid arthritis', Arthritis and Rheumatism, vol. 38, no. 1, pp. 91-95. https://doi.org/10.1002/art.1780380114

TY - JOUR

T1 - The role of t cell receptor β chain genes in susceptibility to rheumatoid arthritis

AU - Mcdermott, Michael

AU - Kastner, Daniel L.

AU - Hsu, Christine

AU - Holloman, John D.

AU - Schmidt‐Wolf, Gabriele

AU - Lundberg, Ante S.

AU - Sinha, Animesh A.

AU - Mcdevitt, Hugh O.

AU - Cashin, Patrick

AU - Molloy, Michael G.

AU - Mulcahy, Brian

AU - O'Gara, Fergal

AU - Mcconnell, Fiona I.

AU - Adams, Claire

AU - Khan, Muhammad A.

AU - Wolfe, Frederick

AU - Rubin, Laurence A.

AU - Clegg, Daniel O.

AU - Husebye, Dee

AU - Amos, Christopher I.

AU - Ward, Ryk H.

PY - 1995/1

Y1 - 1995/1

N2 - Objective. To evaluate the role of the T cell receptor β chain locus TCRB in genetic susceptibility to rheumatoid arthritis (RA). Methods. Twenty‐eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V β6.7), a V β12.2 SSCP marker, and a biallelic Cβ restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity‐by‐descent in affected sib‐pairs. Results. Using the V β12.2 marker, there was suggestive evidence of increased sib‐pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V β6.7 and Cβ yielded significance levels of 0.06 and 0.19, respectively. Conclusion. These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.

AB - Objective. To evaluate the role of the T cell receptor β chain locus TCRB in genetic susceptibility to rheumatoid arthritis (RA). Methods. Twenty‐eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V β6.7), a V β12.2 SSCP marker, and a biallelic Cβ restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity‐by‐descent in affected sib‐pairs. Results. Using the V β12.2 marker, there was suggestive evidence of increased sib‐pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V β6.7 and Cβ yielded significance levels of 0.06 and 0.19, respectively. Conclusion. These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.

UR - https://www.scopus.com/pages/publications/0028857357

U2 - 10.1002/art.1780380114

DO - 10.1002/art.1780380114

M3 - Article

C2 - 7818578

AN - SCOPUS:0028857357

SN - 0004-3591

VL - 38

SP - 91

EP - 95

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 1

ER -

The role of t cell receptor β chain genes in susceptibility to rheumatoid arthritis

Abstract

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