The Role of Fibrinolysis in the Therapy of Peripheral Vascular Disease

Clara M. Ambrus; Julian L. Ambrus; Helmuth Gastpar; Satya D. Sharma; O. W. Suh; Robert H. Moore; Phyllis Williams

doi:10.1177/000331978403500706

The Role of Fibrinolysis in the Therapy of Peripheral Vascular Disease

Clara M. Ambrus
, Julian L. Ambrus
, Helmuth Gastpar
, Satya D. Sharma
, O. W. Suh
, Robert H. Moore
, Phyllis Williams

Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E₁ released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxifylline and prostaglandin E₁ synergized with each other. Pentoxifylline potentiated the thrombolytic effect of prostaglandin E₁ in vivo.

Original language	English
Pages (from-to)	436-442
Number of pages	7
Journal	Angiology
Volume	35
Issue number	7
DOIs	https://doi.org/10.1177/000331978403500706
State	Published - Jul 1984

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title = "The Role of Fibrinolysis in the Therapy of Peripheral Vascular Disease",

abstract = "In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E1 released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxifylline and prostaglandin E1 synergized with each other. Pentoxifylline potentiated the thrombolytic effect of prostaglandin E1 in vivo.",

author = "Ambrus, \{Clara M.\} and Ambrus, \{Julian L.\} and Helmuth Gastpar and Sharma, \{Satya D.\} and Suh, \{O. W.\} and Moore, \{Robert H.\} and Phyllis Williams",

year = "1984",

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AU - Ambrus, Clara M.

AU - Ambrus, Julian L.

AU - Gastpar, Helmuth

AU - Sharma, Satya D.

AU - Suh, O. W.

AU - Moore, Robert H.

AU - Williams, Phyllis

PY - 1984/7

Y1 - 1984/7

N2 - In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E1 released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxifylline and prostaglandin E1 synergized with each other. Pentoxifylline potentiated the thrombolytic effect of prostaglandin E1 in vivo.

AB - In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E1 released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxifylline and prostaglandin E1 synergized with each other. Pentoxifylline potentiated the thrombolytic effect of prostaglandin E1 in vivo.

UR - https://www.scopus.com/pages/publications/0021269352

U2 - 10.1177/000331978403500706

DO - 10.1177/000331978403500706

M3 - Article

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AN - SCOPUS:0021269352

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VL - 35

SP - 436

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JO - Angiology

JF - Angiology

IS - 7

ER -

The Role of Fibrinolysis in the Therapy of Peripheral Vascular Disease

Abstract

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