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The Reign of Follistatin in Tumors and Their Microenvironment: Implications for Drug Resistance

  • SUNY Buffalo
  • Seattle Children's Hospital

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Follistatin (FST) is a potent neutralizer of the transforming growth factor-β superfamily and is associated with normal cellular programs and various hallmarks of cancer, such as proliferation, migration, angiogenesis, and immune evasion. The aberrant expression of FST by solid tumors is a well-documented observation, yet how FST influences tumor progression and therapy response remains unclear. The recent surge in omics data has revealed new insights into the molecular foundation underpinning tumor heterogeneity and its microenvironment, offering novel precision medicine-based opportunities to combat cancer. In this review, we discuss these recent FST-centric studies, thereby offering an updated perspective on the protean role of FST isoforms in shaping the complex cellular ecosystem of tumors and in mediating drug resistance.

Original languageEnglish
Article number130
JournalBiology
Volume13
Issue number2
DOIs
StatePublished - Feb 2024

Keywords

  • cancer hallmarks
  • chemoresistance
  • follistatin
  • squamous cell carcinoma
  • transforming growth factor-beta pathway
  • tumor heterogeneity
  • tumor microenvironment

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