The prolactin-stimulating potency of reserpine in man

Gregory M. Asnis; Edward J. Sachar; Uriel Halbreich; Lynn C. Ostrow; R. Swami Nathan; Frieda S. Halpern

doi:10.1016/0165-1781(81)90059-7

The prolactin-stimulating potency of reserpine in man

Gregory M. Asnis
, Edward J. Sachar
, Uriel Halbreich
, Lynn C. Ostrow
, R. Swami Nathan
, Frieda S. Halpern

Department of Psychiatry

University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The prolactin (PRL) response to 0.5 mg i.m. of reserpine was compared to 0.5 mg i.m. of haloperidol in eight young men. The fact that reserpine was found to be a potent releaser of PRL-significantly greater than haloperidol-suggests a major role of storage pool dopamine in regulating PRL secretion. Since the PRL response to neuroleptics is highly correlated with clinical potency, reserpine could be a potent antipsychotic, and further clinical trials are indicated.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Psychiatry Research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(81)90059-7
State	Published - Aug 1981

Keywords

clinical potency
haloperidol
prolactin response
Reserpine
schizophrenia
storage dopamine

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10.1016/0165-1781(81)90059-7

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title = "The prolactin-stimulating potency of reserpine in man",

abstract = "The prolactin (PRL) response to 0.5 mg i.m. of reserpine was compared to 0.5 mg i.m. of haloperidol in eight young men. The fact that reserpine was found to be a potent releaser of PRL-significantly greater than haloperidol-suggests a major role of storage pool dopamine in regulating PRL secretion. Since the PRL response to neuroleptics is highly correlated with clinical potency, reserpine could be a potent antipsychotic, and further clinical trials are indicated.",

keywords = "clinical potency, haloperidol, prolactin response, Reserpine, schizophrenia, storage dopamine",

author = "Asnis, \{Gregory M.\} and Sachar, \{Edward J.\} and Uriel Halbreich and Ostrow, \{Lynn C.\} and Nathan, \{R. Swami\} and Halpern, \{Frieda S.\}",

year = "1981",

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doi = "10.1016/0165-1781(81)90059-7",

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T1 - The prolactin-stimulating potency of reserpine in man

AU - Asnis, Gregory M.

AU - Sachar, Edward J.

AU - Halbreich, Uriel

AU - Ostrow, Lynn C.

AU - Nathan, R. Swami

AU - Halpern, Frieda S.

PY - 1981/8

Y1 - 1981/8

N2 - The prolactin (PRL) response to 0.5 mg i.m. of reserpine was compared to 0.5 mg i.m. of haloperidol in eight young men. The fact that reserpine was found to be a potent releaser of PRL-significantly greater than haloperidol-suggests a major role of storage pool dopamine in regulating PRL secretion. Since the PRL response to neuroleptics is highly correlated with clinical potency, reserpine could be a potent antipsychotic, and further clinical trials are indicated.

AB - The prolactin (PRL) response to 0.5 mg i.m. of reserpine was compared to 0.5 mg i.m. of haloperidol in eight young men. The fact that reserpine was found to be a potent releaser of PRL-significantly greater than haloperidol-suggests a major role of storage pool dopamine in regulating PRL secretion. Since the PRL response to neuroleptics is highly correlated with clinical potency, reserpine could be a potent antipsychotic, and further clinical trials are indicated.

KW - clinical potency

KW - haloperidol

KW - prolactin response

KW - Reserpine

KW - schizophrenia

KW - storage dopamine

UR - https://www.scopus.com/pages/publications/0019466444

U2 - 10.1016/0165-1781(81)90059-7

DO - 10.1016/0165-1781(81)90059-7

M3 - Article

C2 - 6944708

AN - SCOPUS:0019466444

SN - 0165-1781

VL - 5

SP - 39

EP - 45

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1

ER -

The prolactin-stimulating potency of reserpine in man

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Keywords

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