The next generation of liposome delivery systems: Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients

R. M. Abra; R. B. Bankert; F. Chen; N. K. Egilmez; K. Huang; R. Saville; J. L. Slater; M. Sugano; S. J. Yokota

doi:10.1081/LPR-120004770

The next generation of liposome delivery systems: Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients

R. M. Abra
, R. B. Bankert
, F. Chen
, N. K. Egilmez
, K. Huang
, R. Saville
, J. L. Slater
, M. Sugano
, S. J. Yokota

Microbiology and Immunology

ALZA Corp.
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β₁ integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Journal of Liposome Research
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1081/LPR-120004770
State	Published - 2002

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title = "The next generation of liposome delivery systems: Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients",

abstract = "Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.",

author = "Abra, \{R. M.\} and Bankert, \{R. B.\} and F. Chen and Egilmez, \{N. K.\} and K. Huang and R. Saville and Slater, \{J. L.\} and M. Sugano and Yokota, \{S. J.\}",

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doi = "10.1081/LPR-120004770",

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T1 - The next generation of liposome delivery systems

T2 - Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients

AU - Abra, R. M.

AU - Bankert, R. B.

AU - Chen, F.

AU - Egilmez, N. K.

AU - Huang, K.

AU - Saville, R.

AU - Slater, J. L.

AU - Sugano, M.

AU - Yokota, S. J.

PY - 2002

Y1 - 2002

N2 - Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.

AB - Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.

UR - https://www.scopus.com/pages/publications/0036334957

U2 - 10.1081/LPR-120004770

DO - 10.1081/LPR-120004770

M3 - Article

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AN - SCOPUS:0036334957

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JO - Journal of Liposome Research

JF - Journal of Liposome Research

IS - 1-2

ER -

The next generation of liposome delivery systems: Recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients

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