The molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α-pregn-20-YN-1-one

Charles M. Weeks; William L. Duax; John R. Williams; George M. Sarkisian

doi:10.1016/0039-128X(76)90047-7

The molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α-pregn-20-YN-1-one

Charles M. Weeks
, William L. Duax
, John R. Williams
, George M. Sarkisian

Department of Structural Biology

Hauptman-Woodward Medical Research Institute, Inc.
Temple University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The crystal and molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α -pregn-20-YN-1-one has been determined by X-ray analysis in order to ascertain the configuration at C(10). As observed in most other 17α-pregn-20-yn-17β-ol structures, atom 0(17B) participates as a donor in a hydrogen bond trans to the C(16)-C(17) bond, and there is a short C(21)...0 intermolecular contact.

Original language	English
Pages (from-to)	377-386
Number of pages	10
Journal	Steroids
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/0039-128X(76)90047-7
State	Published - Sep 1976

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title = "The molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α-pregn-20-YN-1-one",

abstract = "The crystal and molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α -pregn-20-YN-1-one has been determined by X-ray analysis in order to ascertain the configuration at C(10). As observed in most other 17α-pregn-20-yn-17β-ol structures, atom 0(17B) participates as a donor in a hydrogen bond trans to the C(16)-C(17) bond, and there is a short C(21)...0 intermolecular contact.",

author = "Weeks, \{Charles M.\} and Duax, \{William L.\} and Williams, \{John R.\} and Sarkisian, \{George M.\}",

year = "1976",

month = sep,

doi = "10.1016/0039-128X(76)90047-7",

language = "English",

volume = "28",

pages = "377--386",

journal = "Steroids",

issn = "0039-128X",

publisher = "Elsevier Inc.",

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T1 - The molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α-pregn-20-YN-1-one

AU - Weeks, Charles M.

AU - Duax, William L.

AU - Williams, John R.

AU - Sarkisian, George M.

PY - 1976/9

Y1 - 1976/9

N2 - The crystal and molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α -pregn-20-YN-1-one has been determined by X-ray analysis in order to ascertain the configuration at C(10). As observed in most other 17α-pregn-20-yn-17β-ol structures, atom 0(17B) participates as a donor in a hydrogen bond trans to the C(16)-C(17) bond, and there is a short C(21)...0 intermolecular contact.

AB - The crystal and molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α -pregn-20-YN-1-one has been determined by X-ray analysis in order to ascertain the configuration at C(10). As observed in most other 17α-pregn-20-yn-17β-ol structures, atom 0(17B) participates as a donor in a hydrogen bond trans to the C(16)-C(17) bond, and there is a short C(21)...0 intermolecular contact.

UR - https://www.scopus.com/pages/publications/0017108650

U2 - 10.1016/0039-128X(76)90047-7

DO - 10.1016/0039-128X(76)90047-7

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AN - SCOPUS:0017108650

SN - 0039-128X

VL - 28

SP - 377

EP - 386

JO - Steroids

JF - Steroids

IS - 3

ER -

The molecular structure of (10R)-17β-hydroxy-5-methylene-4,10-cyclo-19-nor-4,5-seco-17α-pregn-20-YN-1-one

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