The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis

Peter W. Stacpoole; S. T. Bunch; Richard E. Neiberger; Leigh Ann Perkins; Ronald Quisling; Alan D. Hutson; Melvin Greer

doi:10.1016/S0022-3476(99)70379-3

The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis

Peter W. Stacpoole
, S. T. Bunch
, Richard E. Neiberger
, Leigh Ann Perkins
, Ronald Quisling
, Alan D. Hutson
, Melvin Greer

Department of Biostatistics

University of Florida

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean ± SEM difference between these variables was 2.4 ± 0.3 mmol/L (P = .0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	Journal of Pediatrics
Volume	134
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(99)70379-3
State	Published - 1999

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title = "The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis",

abstract = "In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean ± SEM difference between these variables was 2.4 ± 0.3 mmol/L (P = .0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.",

author = "Stacpoole, \{Peter W.\} and Bunch, \{S. T.\} and Neiberger, \{Richard E.\} and Perkins, \{Leigh Ann\} and Ronald Quisling and Hutson, \{Alan D.\} and Melvin Greer",

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AU - Stacpoole, Peter W.

AU - Bunch, S. T.

AU - Neiberger, Richard E.

AU - Perkins, Leigh Ann

AU - Quisling, Ronald

AU - Hutson, Alan D.

AU - Greer, Melvin

PY - 1999

Y1 - 1999

N2 - In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean ± SEM difference between these variables was 2.4 ± 0.3 mmol/L (P = .0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.

AB - In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean ± SEM difference between these variables was 2.4 ± 0.3 mmol/L (P = .0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.

UR - https://www.scopus.com/pages/publications/0032950351

U2 - 10.1016/S0022-3476(99)70379-3

DO - 10.1016/S0022-3476(99)70379-3

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AN - SCOPUS:0032950351

SN - 0022-3476

VL - 134

SP - 99

EP - 102

JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 1

ER -

The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis

Abstract

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