TY - JOUR
T1 - The Impact of Postprocedural Anticoagulant Use in Patients Undergoing Woven EndoBridge
T2 - A Multicenter Propensity Score-Matched Study
AU - Musmar, Basel
AU - Salim, Hamza Adel
AU - Roy, Joanna M.
AU - Adeeb, Nimer
AU - Fuleihan, Antony A.
AU - Atallah, Elias
AU - Sizdahkhani, Saman
AU - Koduri, Sravanthi
AU - Karadimas, Spyridon
AU - Baba, Bachar El
AU - Howard, Brian M.
AU - Grossberg, Jonathan A.
AU - Scott, Kyle W.
AU - Burkhardt, Jan Karl
AU - Srinivasan, Visish M.
AU - Erazu, Fernanda
AU - Hanel, Ricardo A.
AU - Amllay, Abdelaziz
AU - Matouk, Charles
AU - MacNeil, Andrew
AU - Chalouhi, Nohra
AU - Gomez-Paz, Santiago
AU - Grandhi, Ramesh
AU - Jaikumar, Vinay
AU - Levy, Elad
AU - Siddiqui, Adnan
AU - Klaiman, Max
AU - Delgado, Josser
AU - Hoffman, Haydn
AU - Arthur, Adam
AU - Hasan, David M.
AU - Notarianni, Christina
AU - Cuellar, Hugo H.
AU - Guthikonda, Bharat
AU - Morcos, Jacques
AU - Tjoumakaris, Stavropoula I.
AU - Gooch, Michael Reid
AU - Rosenwasser, Robert H.
AU - Jabbour, Pascal
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2025/10
Y1 - 2025/10
N2 - The Woven EndoBridge (WEB) device has become a prominent treatment for wide-neck bifurcation intracranial aneurysms since its FDA approval in 2018. However, the impact of anticoagulant therapy on its efficacy and patient outcomes remains underexplored. This study aims to evaluate the effects of postoperative anticoagulant use on aneurysm occlusion, retreatment rates, and functional outcomes following WEB device implantation. This retrospective multicenter study included 457 patients treated with the WEB device across 10 academic institutions in the United States between January 2012 and June 2024. Patients were categorized based on postoperative anticoagulant use: 91 patients (19.9%) received anticoagulants, while 366 patients (80.1%) did not. Propensity score matching (PSM) was employed to control for potential confounders, resulting in 316 matched patients (229 non-anticoagulant and 87 anticoagulant). After PSM, the anticoagulant group had lower rates of excellent functional outcomes (mRS 0–1: 73% vs. 85%, p = 0.026) and higher mortality rates (6.7% vs. 3.7%, p = 0.33), though the latter difference was not statistically significant. No significant differences in the last follow-up adequate occlusion were observed between the two groups (p = 0.7). However, patients in the anticoagulant group had lower major device compaction (> 50%) (4.9% vs. 12%, p = 0.12) and retreatment rates (4.6% vs. 12%, p = 0.045). Postoperative anticoagulant use is associated with poor functional outcomes and higher tendency for higher mortality rate. No significant differences in the last follow-up adequate occlusion rate were observed between the anticoagulant group and non-anticoagulant group. However, patients in the anticoagulant group had lower major compaction and retreatment rates. These findings suggest that the WEB mechanism of occlusion is more complex than what have been hypothesized and highlight the need for individualized management strategies to optimize outcomes in patients requiring anticoagulation post-WEB. Further studies are needed.
AB - The Woven EndoBridge (WEB) device has become a prominent treatment for wide-neck bifurcation intracranial aneurysms since its FDA approval in 2018. However, the impact of anticoagulant therapy on its efficacy and patient outcomes remains underexplored. This study aims to evaluate the effects of postoperative anticoagulant use on aneurysm occlusion, retreatment rates, and functional outcomes following WEB device implantation. This retrospective multicenter study included 457 patients treated with the WEB device across 10 academic institutions in the United States between January 2012 and June 2024. Patients were categorized based on postoperative anticoagulant use: 91 patients (19.9%) received anticoagulants, while 366 patients (80.1%) did not. Propensity score matching (PSM) was employed to control for potential confounders, resulting in 316 matched patients (229 non-anticoagulant and 87 anticoagulant). After PSM, the anticoagulant group had lower rates of excellent functional outcomes (mRS 0–1: 73% vs. 85%, p = 0.026) and higher mortality rates (6.7% vs. 3.7%, p = 0.33), though the latter difference was not statistically significant. No significant differences in the last follow-up adequate occlusion were observed between the two groups (p = 0.7). However, patients in the anticoagulant group had lower major device compaction (> 50%) (4.9% vs. 12%, p = 0.12) and retreatment rates (4.6% vs. 12%, p = 0.045). Postoperative anticoagulant use is associated with poor functional outcomes and higher tendency for higher mortality rate. No significant differences in the last follow-up adequate occlusion rate were observed between the anticoagulant group and non-anticoagulant group. However, patients in the anticoagulant group had lower major compaction and retreatment rates. These findings suggest that the WEB mechanism of occlusion is more complex than what have been hypothesized and highlight the need for individualized management strategies to optimize outcomes in patients requiring anticoagulation post-WEB. Further studies are needed.
KW - Aneurysm
KW - Anticoagulant
KW - Multicenter
KW - PSM
KW - WEB
UR - https://www.scopus.com/pages/publications/85212822793
U2 - 10.1007/s12975-024-01320-2
DO - 10.1007/s12975-024-01320-2
M3 - Article
C2 - 39715904
AN - SCOPUS:85212822793
SN - 1868-4483
VL - 16
SP - 1486
EP - 1495
JO - Translational Stroke Research
JF - Translational Stroke Research
IS - 5
ER -