The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)

Guohua Wei; Vipin Kumar; Jun Xue; Robert D. Locke; Khushi L. Matta

doi:10.1016/j.tetlet.2009.08.017

The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)

Guohua Wei
, Vipin Kumar
, Jun Xue
, Robert D. Locke
, Khushi L. Matta

Department of Chemical and Biological Engineering

Roswell Park Cancer Institute
CAS - Research Center for Eco-Environmental Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP is described here. This compound can serve as a novel substrate to study the catalytic mechanism of hyaluronic acid synthases (HASs) and has potential to be donor for these enzymes that extend HA chain at the reducing end. Moreover, it may also behave as inhibitor for the enzymes that act on non-reducing end in the assembly of HA chain.

Original language	English
Pages (from-to)	5920-5922
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2009.08.017
State	Published - Oct 28 2009

Keywords

F-4-GlcA
Hyaluronic acid synthases (HASs)
Oligosaccharides
Phosphates

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10.1016/j.tetlet.2009.08.017

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title = "The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)",

abstract = "The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP is described here. This compound can serve as a novel substrate to study the catalytic mechanism of hyaluronic acid synthases (HASs) and has potential to be donor for these enzymes that extend HA chain at the reducing end. Moreover, it may also behave as inhibitor for the enzymes that act on non-reducing end in the assembly of HA chain.",

keywords = "F-4-GlcA, Hyaluronic acid synthases (HASs), Oligosaccharides, Phosphates",

author = "Guohua Wei and Vipin Kumar and Jun Xue and Locke, \{Robert D.\} and Matta, \{Khushi L.\}",

year = "2009",

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T1 - The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)

AU - Wei, Guohua

AU - Kumar, Vipin

AU - Xue, Jun

AU - Locke, Robert D.

AU - Matta, Khushi L.

PY - 2009/10/28

Y1 - 2009/10/28

N2 - The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP is described here. This compound can serve as a novel substrate to study the catalytic mechanism of hyaluronic acid synthases (HASs) and has potential to be donor for these enzymes that extend HA chain at the reducing end. Moreover, it may also behave as inhibitor for the enzymes that act on non-reducing end in the assembly of HA chain.

AB - The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP is described here. This compound can serve as a novel substrate to study the catalytic mechanism of hyaluronic acid synthases (HASs) and has potential to be donor for these enzymes that extend HA chain at the reducing end. Moreover, it may also behave as inhibitor for the enzymes that act on non-reducing end in the assembly of HA chain.

KW - F-4-GlcA

KW - Hyaluronic acid synthases (HASs)

KW - Oligosaccharides

KW - Phosphates

UR - https://www.scopus.com/pages/publications/69849094939

U2 - 10.1016/j.tetlet.2009.08.017

DO - 10.1016/j.tetlet.2009.08.017

M3 - Article

AN - SCOPUS:69849094939

SN - 0040-4039

VL - 50

SP - 5920

EP - 5922

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

The first chemical synthesis of F-4-GlcAβ(1→3)GlcNAc-UDP with the potential of novel substrate and enzyme inhibitor for hyaluronic acid synthases (HASs)

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Keywords

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