The effects of β-carbolines in rats trained with ibogaine as a discriminative stimulus

Scott Helsley; Richard A. Rabin; J. C. Winter

doi:10.1016/S0014-2999(98)00002-8

The effects of β-carbolines in rats trained with ibogaine as a discriminative stimulus

Scott Helsley
, Richard A. Rabin
, J. C. Winter

Pharmacology and Toxicology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The structural features and hallucinogenic properties shared by ibogaine and certain β-carbolines prompted the evaluation of several representative β-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-β-carboline (THBC). Norharmane and 6,7- dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine- like effect of certain β-carbolines. Whether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.

Original language	English
Pages (from-to)	139-143
Number of pages	5
Journal	European Journal of Pharmacology
Volume	345
Issue number	2
DOIs	https://doi.org/10.1016/S0014-2999(98)00002-8
State	Published - Mar 19 1998

Keywords

Drug-induced stimulus control
Hallucinogen
Ibogaine
β-Carboline

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10.1016/S0014-2999(98)00002-8

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title = "The effects of β-carbolines in rats trained with ibogaine as a discriminative stimulus",

abstract = "The structural features and hallucinogenic properties shared by ibogaine and certain β-carbolines prompted the evaluation of several representative β-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5\%). In the present study, only 6-methoxyharmalan completely substituted (86.3\%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-β-carboline (THBC). Norharmane and 6,7- dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine- like effect of certain β-carbolines. Whether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.",

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AU - Helsley, Scott

AU - Rabin, Richard A.

AU - Winter, J. C.

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Y1 - 1998/3/19

N2 - The structural features and hallucinogenic properties shared by ibogaine and certain β-carbolines prompted the evaluation of several representative β-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-β-carboline (THBC). Norharmane and 6,7- dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine- like effect of certain β-carbolines. Whether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.

AB - The structural features and hallucinogenic properties shared by ibogaine and certain β-carbolines prompted the evaluation of several representative β-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-β-carboline (THBC). Norharmane and 6,7- dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine- like effect of certain β-carbolines. Whether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.

KW - Drug-induced stimulus control

KW - Hallucinogen

KW - Ibogaine

KW - β-Carboline

UR - https://www.scopus.com/pages/publications/0032546324

U2 - 10.1016/S0014-2999(98)00002-8

DO - 10.1016/S0014-2999(98)00002-8

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JO - European Journal of Pharmacology

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ER -

The effects of β-carbolines in rats trained with ibogaine as a discriminative stimulus

Abstract

Keywords

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