The effect of tiaprofenic acid and indomethacin on in vitro prostaglandin synthesis by rat, rabbit and human stomach tissue

J. Y. Jeremy; D. P. Mikhailidis; P. Dandona

doi:10.1007/BF01966593

The effect of tiaprofenic acid and indomethacin on in vitro prostaglandin synthesis by rat, rabbit and human stomach tissue

J. Y. Jeremy
, D. P. Mikhailidis
, P. Dandona

Medicine

Royal Free London NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We compared the inhibitory effect of two non-steroidal anti-inflammatory drugs (NSAIDs), tiaprofenic acid and indomethacin, on in vitro prostaglandin (PG) synthesis by human, rat and rabbit stomach/duodenal tissue. Both drugs were equipotent inhibitors of PGE₂, 6-oxo-PGF_1α (the stable metabolite of prostacyclin, PGI₂) and PGF_2α. These findings suggest that tiaprofenic acid does not offer 'gastric protection' by sparing the cytoprotective PGs, as previously claimed. Our in vitro findings are in agreement with the results of clinical trials which show that faecal blood loss and epigastric discomfort are of a similar pattern whether tiaprofenic acid or other NSAIDs are administered.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	Agents and Actions
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/BF01966593
State	Published - Dec 1985

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abstract = "We compared the inhibitory effect of two non-steroidal anti-inflammatory drugs (NSAIDs), tiaprofenic acid and indomethacin, on in vitro prostaglandin (PG) synthesis by human, rat and rabbit stomach/duodenal tissue. Both drugs were equipotent inhibitors of PGE2, 6-oxo-PGF1α (the stable metabolite of prostacyclin, PGI2) and PGF2α. These findings suggest that tiaprofenic acid does not offer 'gastric protection' by sparing the cytoprotective PGs, as previously claimed. Our in vitro findings are in agreement with the results of clinical trials which show that faecal blood loss and epigastric discomfort are of a similar pattern whether tiaprofenic acid or other NSAIDs are administered.",

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AU - Dandona, P.

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N2 - We compared the inhibitory effect of two non-steroidal anti-inflammatory drugs (NSAIDs), tiaprofenic acid and indomethacin, on in vitro prostaglandin (PG) synthesis by human, rat and rabbit stomach/duodenal tissue. Both drugs were equipotent inhibitors of PGE2, 6-oxo-PGF1α (the stable metabolite of prostacyclin, PGI2) and PGF2α. These findings suggest that tiaprofenic acid does not offer 'gastric protection' by sparing the cytoprotective PGs, as previously claimed. Our in vitro findings are in agreement with the results of clinical trials which show that faecal blood loss and epigastric discomfort are of a similar pattern whether tiaprofenic acid or other NSAIDs are administered.

AB - We compared the inhibitory effect of two non-steroidal anti-inflammatory drugs (NSAIDs), tiaprofenic acid and indomethacin, on in vitro prostaglandin (PG) synthesis by human, rat and rabbit stomach/duodenal tissue. Both drugs were equipotent inhibitors of PGE2, 6-oxo-PGF1α (the stable metabolite of prostacyclin, PGI2) and PGF2α. These findings suggest that tiaprofenic acid does not offer 'gastric protection' by sparing the cytoprotective PGs, as previously claimed. Our in vitro findings are in agreement with the results of clinical trials which show that faecal blood loss and epigastric discomfort are of a similar pattern whether tiaprofenic acid or other NSAIDs are administered.

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The effect of tiaprofenic acid and indomethacin on in vitro prostaglandin synthesis by rat, rabbit and human stomach tissue

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