The dexamethasone suppression test in depressive illness: Clinical correlates

Gregory M. Asnis; Uriel Halbreich; R. Swami Nathan; Lynn Ostrow; Hana Novacenko; Jean Endicott; Edward J. Sachar

doi:10.1016/0306-4530(82)90033-6

The dexamethasone suppression test in depressive illness: Clinical correlates

Gregory M. Asnis
, Uriel Halbreich
, R. Swami Nathan
, Lynn Ostrow
, Hana Novacenko
, Jean Endicott
, Edward J. Sachar

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Clinical correlates of endogenous depression which may be associated with dexamethasone resistance have been evaluated by many investigators and found to be inconclusive. The authors investigated in 40 endogenously depressed patients the relationship of the dexamethasone suppression test (DST) and various clinical correlates - SADS scales, Research Diagnostic Criteria (RDC) depressive subtypes, family history from the FHRDC, responsivity to antidepressant treatment, etc. Dexamethasone resistance was found to be significantly associated with psychotic and bipolar depression but unrelated to the other clinical correlates examined. These findings are limited to the 2 mg DST; clinical correlates associated with non-suppression to dexamethasone may be related to the dose of dexamethasone.

Original language	English
Pages (from-to)	295-301
Number of pages	7
Journal	Psychoneuroendocrinology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/0306-4530(82)90033-6
State	Published - 1982

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title = "The dexamethasone suppression test in depressive illness: Clinical correlates",

abstract = "Clinical correlates of endogenous depression which may be associated with dexamethasone resistance have been evaluated by many investigators and found to be inconclusive. The authors investigated in 40 endogenously depressed patients the relationship of the dexamethasone suppression test (DST) and various clinical correlates - SADS scales, Research Diagnostic Criteria (RDC) depressive subtypes, family history from the FHRDC, responsivity to antidepressant treatment, etc. Dexamethasone resistance was found to be significantly associated with psychotic and bipolar depression but unrelated to the other clinical correlates examined. These findings are limited to the 2 mg DST; clinical correlates associated with non-suppression to dexamethasone may be related to the dose of dexamethasone.",

author = "Asnis, \{Gregory M.\} and Uriel Halbreich and Nathan, \{R. Swami\} and Lynn Ostrow and Hana Novacenko and Jean Endicott and Sachar, \{Edward J.\}",

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T1 - The dexamethasone suppression test in depressive illness

T2 - Clinical correlates

AU - Asnis, Gregory M.

AU - Halbreich, Uriel

AU - Nathan, R. Swami

AU - Ostrow, Lynn

AU - Novacenko, Hana

AU - Endicott, Jean

AU - Sachar, Edward J.

PY - 1982

Y1 - 1982

N2 - Clinical correlates of endogenous depression which may be associated with dexamethasone resistance have been evaluated by many investigators and found to be inconclusive. The authors investigated in 40 endogenously depressed patients the relationship of the dexamethasone suppression test (DST) and various clinical correlates - SADS scales, Research Diagnostic Criteria (RDC) depressive subtypes, family history from the FHRDC, responsivity to antidepressant treatment, etc. Dexamethasone resistance was found to be significantly associated with psychotic and bipolar depression but unrelated to the other clinical correlates examined. These findings are limited to the 2 mg DST; clinical correlates associated with non-suppression to dexamethasone may be related to the dose of dexamethasone.

AB - Clinical correlates of endogenous depression which may be associated with dexamethasone resistance have been evaluated by many investigators and found to be inconclusive. The authors investigated in 40 endogenously depressed patients the relationship of the dexamethasone suppression test (DST) and various clinical correlates - SADS scales, Research Diagnostic Criteria (RDC) depressive subtypes, family history from the FHRDC, responsivity to antidepressant treatment, etc. Dexamethasone resistance was found to be significantly associated with psychotic and bipolar depression but unrelated to the other clinical correlates examined. These findings are limited to the 2 mg DST; clinical correlates associated with non-suppression to dexamethasone may be related to the dose of dexamethasone.

UR - https://www.scopus.com/pages/publications/0020351032

U2 - 10.1016/0306-4530(82)90033-6

DO - 10.1016/0306-4530(82)90033-6

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AN - SCOPUS:0020351032

SN - 0306-4530

VL - 7

SP - 295

EP - 301

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

IS - 4

ER -

The dexamethasone suppression test in depressive illness: Clinical correlates

Abstract

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