The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives

Karen L. Milkiewicz; Thomas H. Marsilje; Richard P. Woodworth; Neil Bifulco; Matthew J. Hangauer; David G. Hangauer

doi:10.1016/S0960-894X(00)00040-8

The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives

Karen L. Milkiewicz
, Thomas H. Marsilje
, Richard P. Woodworth
, Neil Bifulco
, Matthew J. Hangauer
, David G. Hangauer

Chemistry

SUNY Buffalo
Scripps Research Institute

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

As part of continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	483-486
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(00)00040-8
State	Published - Mar 6 2000

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abstract = "As part of continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.",

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AU - Woodworth, Richard P.

AU - Bifulco, Neil

AU - Hangauer, Matthew J.

AU - Hangauer, David G.

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AB - As part of continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.

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IS - 5

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The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives

Abstract

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