The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase. Part 1: Hydroxynaphthalene derivatives

Thomas H. Marsilje; Karen L. Milkiewicz; David G. Hangauer

doi:10.1016/S0960-894X(00)00039-1

The design, synthesis and activity of non-ATP competitive inhibitors of pp60^c-src tyrosine kinase. Part 1: Hydroxynaphthalene derivatives

Thomas H. Marsilje
, Karen L. Milkiewicz
, David G. Hangauer

Chemistry

SUNY Buffalo
Scripps Research Institute

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A series of hydroxynaphthalene pp60^c-src non-peptide inhibitors was designed, using the crystal structure of the insulin receptor tyrosine kinase as a qualitative model, to target the peptide substrate binding site. Representative inhibitors were shown to bind non-competitively with respect to ATP.

Original language	English
Pages (from-to)	477-481
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(00)00039-1
State	Published - Mar 6 2000

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title = "The design, synthesis and activity of non-ATP competitive inhibitors of pp60c-src tyrosine kinase. Part 1: Hydroxynaphthalene derivatives",

abstract = "A series of hydroxynaphthalene pp60c-src non-peptide inhibitors was designed, using the crystal structure of the insulin receptor tyrosine kinase as a qualitative model, to target the peptide substrate binding site. Representative inhibitors were shown to bind non-competitively with respect to ATP.",

author = "Marsilje, \{Thomas H.\} and Milkiewicz, \{Karen L.\} and Hangauer, \{David G.\}",

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AU - Hangauer, David G.

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AB - A series of hydroxynaphthalene pp60c-src non-peptide inhibitors was designed, using the crystal structure of the insulin receptor tyrosine kinase as a qualitative model, to target the peptide substrate binding site. Representative inhibitors were shown to bind non-competitively with respect to ATP.

UR - https://www.scopus.com/pages/publications/0034611368

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DO - 10.1016/S0960-894X(00)00039-1

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IS - 5

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The design, synthesis and activity of non-ATP competitive inhibitors of pp60^c-src tyrosine kinase. Part 1: Hydroxynaphthalene derivatives

Abstract

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