The design and synthesis of substituted biphenyl libraries

Michael R. Pavia; Michael P. Cohen; Garrett J. Dilley; Gloria R. Dubuc; Tracy L. Durgin; Frank W. Forman; Mark E. Hediger; Guy Milot; Timothy S. Powers; Irving Sucholeiki; Shulan Zhou; David G. Hangauer

doi:10.1016/0968-0896(96)00060-0

The design and synthesis of substituted biphenyl libraries

Michael R. Pavia
, Michael P. Cohen
, Garrett J. Dilley
, Gloria R. Dubuc
, Tracy L. Durgin
, Frank W. Forman
, Mark E. Hediger
, Guy Milot
, Timothy S. Powers
, Irving Sucholeiki
, Shulan Zhou
, David G. Hangauer

Chemistry

Eli Lilly

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.

Original language	English
Pages (from-to)	659-666
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/0968-0896(96)00060-0
State	Published - May 1996

Keywords

Biphenyl
Library
Multiple simultaneous synthesis
Solid-phase synthesis

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10.1016/0968-0896(96)00060-0

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title = "The design and synthesis of substituted biphenyl libraries",

abstract = "A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.",

keywords = "Biphenyl, Library, Multiple simultaneous synthesis, Solid-phase synthesis",

author = "Pavia, \{Michael R.\} and Cohen, \{Michael P.\} and Dilley, \{Garrett J.\} and Dubuc, \{Gloria R.\} and Durgin, \{Tracy L.\} and Forman, \{Frank W.\} and Hediger, \{Mark E.\} and Guy Milot and Powers, \{Timothy S.\} and Irving Sucholeiki and Shulan Zhou and Hangauer, \{David G.\}",

year = "1996",

month = may,

doi = "10.1016/0968-0896(96)00060-0",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry",

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T1 - The design and synthesis of substituted biphenyl libraries

AU - Pavia, Michael R.

AU - Cohen, Michael P.

AU - Dilley, Garrett J.

AU - Dubuc, Gloria R.

AU - Durgin, Tracy L.

AU - Forman, Frank W.

AU - Hediger, Mark E.

AU - Milot, Guy

AU - Powers, Timothy S.

AU - Sucholeiki, Irving

AU - Zhou, Shulan

AU - Hangauer, David G.

PY - 1996/5

Y1 - 1996/5

N2 - A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.

AB - A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.

KW - Biphenyl

KW - Library

KW - Multiple simultaneous synthesis

KW - Solid-phase synthesis

UR - https://www.scopus.com/pages/publications/0029937132

U2 - 10.1016/0968-0896(96)00060-0

DO - 10.1016/0968-0896(96)00060-0

M3 - Article

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AN - SCOPUS:0029937132

SN - 0968-0896

VL - 4

SP - 659

EP - 666

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 5

ER -

The design and synthesis of substituted biphenyl libraries

Abstract

Keywords

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