The beta subunit, Kvβ1.2, Acts as a rapid open channel blocker of NH₂- Terminal deleted Kv1.4 α-Subunits

A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of α-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kvβ1.2, modifies intrinsic α- subunit C-type inactivation. N-type inactivation and open channel black have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kvβl.2 has kinetic properties which are consistent with rapid open channel block.