The area of 2-[125I]iodomelatonin binding in the pars tuberalis of the ground squirrel is decreased during hibernation

Toni L. Stanton; Judith A. Siuciak; Margarita L. Dubocovich; Diana N. Krause

doi:10.1016/0006-8993(91)90145-L

The area of 2-[¹²⁵I]iodomelatonin binding in the pars tuberalis of the ground squirrel is decreased during hibernation

Toni L. Stanton
, Judith A. Siuciak
, Margarita L. Dubocovich
, Diana N. Krause

Pharmacology and Toxicology

California State University Long Beach
Northwestern University
University of California at Irvine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Quantitative receptor autoradiography was used to analyze 2-[¹²⁵I]iodomelatonin binding sites in the brains of golden-mantled ground squirrels (Citellus lateralis). Specific binding appeared to be discretely localized to the pars tuberalis region of the pituitary that surrounds the medial basal hypothalamus. The total area of binding was significantly decreased in brains of hibernating squirrels as compared to those of awake, euthermic animals. These findings support a role for melatonin receptors of the pars tuberalis in seasonal behavior.

Original language	English
Pages (from-to)	285-288
Number of pages	4
Journal	Brain Research
Volume	557
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)90145-L
State	Published - Aug 23 1991

Keywords

2-[I]iodomelatonin binding
Ground squirrel
Hibernation
Melatonin
Pars tuberalis
Receptor autoradiography

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10.1016/0006-8993(91)90145-L

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title = "The area of 2-[125I]iodomelatonin binding in the pars tuberalis of the ground squirrel is decreased during hibernation",

abstract = "Quantitative receptor autoradiography was used to analyze 2-[125I]iodomelatonin binding sites in the brains of golden-mantled ground squirrels (Citellus lateralis). Specific binding appeared to be discretely localized to the pars tuberalis region of the pituitary that surrounds the medial basal hypothalamus. The total area of binding was significantly decreased in brains of hibernating squirrels as compared to those of awake, euthermic animals. These findings support a role for melatonin receptors of the pars tuberalis in seasonal behavior.",

keywords = "2-[I]iodomelatonin binding, Ground squirrel, Hibernation, Melatonin, Pars tuberalis, Receptor autoradiography",

author = "Stanton, \{Toni L.\} and Siuciak, \{Judith A.\} and Dubocovich, \{Margarita L.\} and Krause, \{Diana N.\}",

year = "1991",

month = aug,

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doi = "10.1016/0006-8993(91)90145-L",

language = "English",

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pages = "285--288",

journal = "Brain Research",

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T1 - The area of 2-[125I]iodomelatonin binding in the pars tuberalis of the ground squirrel is decreased during hibernation

AU - Stanton, Toni L.

AU - Siuciak, Judith A.

AU - Dubocovich, Margarita L.

AU - Krause, Diana N.

PY - 1991/8/23

Y1 - 1991/8/23

N2 - Quantitative receptor autoradiography was used to analyze 2-[125I]iodomelatonin binding sites in the brains of golden-mantled ground squirrels (Citellus lateralis). Specific binding appeared to be discretely localized to the pars tuberalis region of the pituitary that surrounds the medial basal hypothalamus. The total area of binding was significantly decreased in brains of hibernating squirrels as compared to those of awake, euthermic animals. These findings support a role for melatonin receptors of the pars tuberalis in seasonal behavior.

AB - Quantitative receptor autoradiography was used to analyze 2-[125I]iodomelatonin binding sites in the brains of golden-mantled ground squirrels (Citellus lateralis). Specific binding appeared to be discretely localized to the pars tuberalis region of the pituitary that surrounds the medial basal hypothalamus. The total area of binding was significantly decreased in brains of hibernating squirrels as compared to those of awake, euthermic animals. These findings support a role for melatonin receptors of the pars tuberalis in seasonal behavior.

KW - 2-[I]iodomelatonin binding

KW - Ground squirrel

KW - Hibernation

KW - Melatonin

KW - Pars tuberalis

KW - Receptor autoradiography

UR - https://www.scopus.com/pages/publications/0025918330

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DO - 10.1016/0006-8993(91)90145-L

M3 - Article

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AN - SCOPUS:0025918330

SN - 0006-8993

VL - 557

SP - 285

EP - 288

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

The area of 2-[¹²⁵I]iodomelatonin binding in the pars tuberalis of the ground squirrel is decreased during hibernation

Abstract

Keywords

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