The application of nanoparticle in BBB transmigration

Gai Xia Xu; Ken Tye Yong; Roy Indrajit; Jun Le Qu; Dan Ni Chen; Xiao Mei Wang; Prasad N. Paras; Hanben Niu

The application of nanoparticle in BBB transmigration

Gai Xia Xu
, Ken Tye Yong
, Roy Indrajit
, Jun Le Qu
, Dan Ni Chen
, Xiao Mei Wang
, Prasad N. Paras
, Hanben Niu

Chemistry

Shenzhen University
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Recently, the advancements in nanotechnology and better understanding of the BBB physiology have promoted the use of nanoparticles for targeted delivery across the BBB for therapy of neuronal diseases/disorders. This review summarizes the applications of several classes of novel nanoparticles to blood-brain barrier (BBB) for therapy, diagnosis, dynamic imaging, and multifunctional mode, including the materials, functions characteristics, as well as their current research status. Our recent progress on visualization of targeted nanoparticle delivery across BBB is also introduced. Finally, the research trend of using nanoparticles for transmigration across BBB and treatment of brain diseases has been highlighted.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Shenzhen Daxue Xuebao (Ligong Ban)/Journal of Shenzhen University Science and Engineering
Volume	26
Issue number	1
State	Published - Jan 2009

Keywords

Blood-brain barrier
Gold nanoparticle
Magnetic nanoparticle
Nanoparticle
Quantum rods

Cite this

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abstract = "Recently, the advancements in nanotechnology and better understanding of the BBB physiology have promoted the use of nanoparticles for targeted delivery across the BBB for therapy of neuronal diseases/disorders. This review summarizes the applications of several classes of novel nanoparticles to blood-brain barrier (BBB) for therapy, diagnosis, dynamic imaging, and multifunctional mode, including the materials, functions characteristics, as well as their current research status. Our recent progress on visualization of targeted nanoparticle delivery across BBB is also introduced. Finally, the research trend of using nanoparticles for transmigration across BBB and treatment of brain diseases has been highlighted.",

keywords = "Blood-brain barrier, Gold nanoparticle, Magnetic nanoparticle, Nanoparticle, Quantum rods",

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AU - Indrajit, Roy

AU - Qu, Jun Le

AU - Chen, Dan Ni

AU - Wang, Xiao Mei

AU - Paras, Prasad N.

AU - Niu, Hanben

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AB - Recently, the advancements in nanotechnology and better understanding of the BBB physiology have promoted the use of nanoparticles for targeted delivery across the BBB for therapy of neuronal diseases/disorders. This review summarizes the applications of several classes of novel nanoparticles to blood-brain barrier (BBB) for therapy, diagnosis, dynamic imaging, and multifunctional mode, including the materials, functions characteristics, as well as their current research status. Our recent progress on visualization of targeted nanoparticle delivery across BBB is also introduced. Finally, the research trend of using nanoparticles for transmigration across BBB and treatment of brain diseases has been highlighted.

KW - Blood-brain barrier

KW - Gold nanoparticle

KW - Magnetic nanoparticle

KW - Nanoparticle

KW - Quantum rods

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The application of nanoparticle in BBB transmigration

Abstract

Keywords

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