Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium

Georgia Martimianaki; Gianfranco Alicandro; Claudio Pelucchi; Rossella Bonzi; Matteo Rota; Jinfu Hu; Kenneth C. Johnson; Charles S. Rabkin; Linda M. Liao; Rashmi Sinha; Zuo Feng Zhang; Michela Dalmartello; Nuno Lunet; Samantha Morais; Domenico Palli; Monica Ferraroni; Guo Pei Yu; Shoichiro Tsugane; Akihisa Hidaka; Maria Paula Curado; Emmanuel Dias-Neto; David Zaridze; Dmitry Maximovitch; Jesus Vioque; Manoli Garcia de la Hera; Lizbeth López-Carrillo; Raúl Ulises Hernández-Ramírez; Gerson Shigueaki Hamada; Mary H. Ward; Lina Mu; Reza Malekzadeh; Farhad Pourfarzi; Antonia Trichopoulou; Anna Karakatsani; Robert C. Kurtz; Areti Lagiou; Pagona Lagiou; Stefania Boccia; Paolo Boffetta; M. Constanza Camargo; Eva Negri; Carlo La Vecchia

doi:10.1038/s41416-022-01856-w

Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium

Georgia Martimianaki
, Gianfranco Alicandro
, Claudio Pelucchi
, Rossella Bonzi
, Matteo Rota
, Jinfu Hu
, Kenneth C. Johnson
, Charles S. Rabkin
, Linda M. Liao
, Rashmi Sinha
, Zuo Feng Zhang
, Michela Dalmartello
, Nuno Lunet
, Samantha Morais
, Domenico Palli
, Monica Ferraroni
, Guo Pei Yu
, Shoichiro Tsugane
, Akihisa Hidaka
, Maria Paula Curado

Emmanuel Dias-Neto, David Zaridze, Dmitry Maximovitch, Jesus Vioque, Manoli Garcia de la Hera, Lizbeth López-Carrillo, Raúl Ulises Hernández-Ramírez, Gerson Shigueaki Hamada, Mary H. Ward, Lina Mu, Reza Malekzadeh, Farhad Pourfarzi, Antonia Trichopoulou, Anna Karakatsani, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Stefania Boccia, Paolo Boffetta, M. Constanza Camargo, Eva Negri, Carlo La Vecchia

Department of Epidemiology and Environmental Health

University of Milan
Helenic Health Foundation
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
University of Brescia
Harbin Medical University
University of Ottawa
National Institutes of Health
University of California at Los Angeles
University of Porto
Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR)
Institute for the Study and Prevention of Cancer
Peking University
National Cancer Center Japan
National Institutes of Biomedical Innovation, Health and Nutrition
A.C.Camargo Cancer Center
Russian N.N. Blokhin Cancer Research Centre
Centro de Investigación Biomédicaen Red de Epidemiología y Salud Pública (CIBERESP)
Miguel Hernández University
Instituto Nacional de Salud Publica
Yale University
Nikkei Disease Prevention Center
Tehran University of Medical Sciences
Ardabil University of Medical Sciences
National and Kapodistrian University of Athens
Memorial Sloan-Kettering Cancer Center
University of West Attica
Harvard University
Catholic University of the Sacred Heart
Fondazione Policlinico Universitario A. Gemelli IRCCS
Stony Brook University
University of Bologna
Pegaso Telematic University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Background: Evidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer. Results: Compared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95% CI: 0.85–0.97). When the amount of tea consumed was considered, the OR for consumption of 1–2 cups/day was 1.01 (95% CI: 0.94–1.09) and for >3 cups/day was 0.91 (95% CI: 0.80–1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95% CI: 0.49–0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95% CI: 0.58–0.80), and for gastric cardia cancer (OR: 0.64, 95% CI: 0.49–0.84). Conclusion: Our results indicate a weak inverse association between tea consumption and gastric cancer.

Original language	English
Pages (from-to)	726-734
Number of pages	9
Journal	British Journal of Cancer
Volume	127
Issue number	4
DOIs	https://doi.org/10.1038/s41416-022-01856-w
State	Published - Sep 1 2022

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Martimianaki, G., Alicandro, G., Pelucchi, C., Bonzi, R., Rota, M., Hu, J., Johnson, K. C., Rabkin, C. S., Liao, L. M., Sinha, R., Zhang, Z. F., Dalmartello, M., Lunet, N., Morais, S., Palli, D., Ferraroni, M., Yu, G. P., Tsugane, S., Hidaka, A., ... La Vecchia, C. (2022). Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium. British Journal of Cancer, 127(4), 726-734. https://doi.org/10.1038/s41416-022-01856-w

@article{e9097455dd0b4c118840b22597a7e5a4,

title = "Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium",

abstract = "Background: Evidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95\% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer. Results: Compared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95\% CI: 0.85–0.97). When the amount of tea consumed was considered, the OR for consumption of 1–2 cups/day was 1.01 (95\% CI: 0.94–1.09) and for >3 cups/day was 0.91 (95\% CI: 0.80–1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95\% CI: 0.49–0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95\% CI: 0.58–0.80), and for gastric cardia cancer (OR: 0.64, 95\% CI: 0.49–0.84). Conclusion: Our results indicate a weak inverse association between tea consumption and gastric cancer.",

author = "Georgia Martimianaki and Gianfranco Alicandro and Claudio Pelucchi and Rossella Bonzi and Matteo Rota and Jinfu Hu and Johnson, \{Kenneth C.\} and Rabkin, \{Charles S.\} and Liao, \{Linda M.\} and Rashmi Sinha and Zhang, \{Zuo Feng\} and Michela Dalmartello and Nuno Lunet and Samantha Morais and Domenico Palli and Monica Ferraroni and Yu, \{Guo Pei\} and Shoichiro Tsugane and Akihisa Hidaka and Curado, \{Maria Paula\} and Emmanuel Dias-Neto and David Zaridze and Dmitry Maximovitch and Jesus Vioque and \{Garcia de la Hera\}, Manoli and Lizbeth L{\'o}pez-Carrillo and Hern{\'a}ndez-Ram{\'i}rez, \{Ra{\'u}l Ulises\} and Hamada, \{Gerson Shigueaki\} and Ward, \{Mary H.\} and Lina Mu and Reza Malekzadeh and Farhad Pourfarzi and Antonia Trichopoulou and Anna Karakatsani and Kurtz, \{Robert C.\} and Areti Lagiou and Pagona Lagiou and Stefania Boccia and Paolo Boffetta and Camargo, \{M. Constanza\} and Eva Negri and \{La Vecchia\}, Carlo",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2022",

month = sep,

day = "1",

doi = "10.1038/s41416-022-01856-w",

language = "English",

volume = "127",

pages = "726--734",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "4",

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Martimianaki, G, Alicandro, G, Pelucchi, C, Bonzi, R, Rota, M, Hu, J, Johnson, KC, Rabkin, CS, Liao, LM, Sinha, R, Zhang, ZF, Dalmartello, M, Lunet, N, Morais, S, Palli, D, Ferraroni, M, Yu, GP, Tsugane, S, Hidaka, A, Curado, MP, Dias-Neto, E, Zaridze, D, Maximovitch, D, Vioque, J, Garcia de la Hera, M, López-Carrillo, L, Hernández-Ramírez, RU, Hamada, GS, Ward, MH, Mu, L, Malekzadeh, R, Pourfarzi, F, Trichopoulou, A, Karakatsani, A, Kurtz, RC, Lagiou, A, Lagiou, P, Boccia, S, Boffetta, P, Camargo, MC, Negri, E & La Vecchia, C 2022, 'Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium', British Journal of Cancer, vol. 127, no. 4, pp. 726-734. https://doi.org/10.1038/s41416-022-01856-w

TY - JOUR

T1 - Tea consumption and gastric cancer

T2 - a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium

AU - Martimianaki, Georgia

AU - Alicandro, Gianfranco

AU - Pelucchi, Claudio

AU - Bonzi, Rossella

AU - Rota, Matteo

AU - Hu, Jinfu

AU - Johnson, Kenneth C.

AU - Rabkin, Charles S.

AU - Liao, Linda M.

AU - Sinha, Rashmi

AU - Zhang, Zuo Feng

AU - Dalmartello, Michela

AU - Lunet, Nuno

AU - Morais, Samantha

AU - Palli, Domenico

AU - Ferraroni, Monica

AU - Yu, Guo Pei

AU - Tsugane, Shoichiro

AU - Hidaka, Akihisa

AU - Curado, Maria Paula

AU - Dias-Neto, Emmanuel

AU - Zaridze, David

AU - Maximovitch, Dmitry

AU - Vioque, Jesus

AU - Garcia de la Hera, Manoli

AU - López-Carrillo, Lizbeth

AU - Hernández-Ramírez, Raúl Ulises

AU - Hamada, Gerson Shigueaki

AU - Ward, Mary H.

AU - Mu, Lina

AU - Malekzadeh, Reza

AU - Pourfarzi, Farhad

AU - Trichopoulou, Antonia

AU - Karakatsani, Anna

AU - Kurtz, Robert C.

AU - Lagiou, Areti

AU - Lagiou, Pagona

AU - Boccia, Stefania

AU - Boffetta, Paolo

AU - Camargo, M. Constanza

AU - Negri, Eva

AU - La Vecchia, Carlo

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Background: Evidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer. Results: Compared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95% CI: 0.85–0.97). When the amount of tea consumed was considered, the OR for consumption of 1–2 cups/day was 1.01 (95% CI: 0.94–1.09) and for >3 cups/day was 0.91 (95% CI: 0.80–1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95% CI: 0.49–0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95% CI: 0.58–0.80), and for gastric cardia cancer (OR: 0.64, 95% CI: 0.49–0.84). Conclusion: Our results indicate a weak inverse association between tea consumption and gastric cancer.

AB - Background: Evidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer. Results: Compared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95% CI: 0.85–0.97). When the amount of tea consumed was considered, the OR for consumption of 1–2 cups/day was 1.01 (95% CI: 0.94–1.09) and for >3 cups/day was 0.91 (95% CI: 0.80–1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95% CI: 0.49–0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95% CI: 0.58–0.80), and for gastric cardia cancer (OR: 0.64, 95% CI: 0.49–0.84). Conclusion: Our results indicate a weak inverse association between tea consumption and gastric cancer.

UR - https://www.scopus.com/pages/publications/85130711801

U2 - 10.1038/s41416-022-01856-w

DO - 10.1038/s41416-022-01856-w

M3 - Article

C2 - 35610368

AN - SCOPUS:85130711801

SN - 0007-0920

VL - 127

SP - 726

EP - 734

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 4

ER -

Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium

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