Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

Kai Uwe Lewandrowski; Kenneth Blum; Alexander P.L. Lewandrowski; Panayotis K. Thanos; Albert Pinhasov; Alireza Sharafshah; David Baron; Mark S. Gold; Catherine A. Dennen; Igor Elman; Aballa Bowirrat; Edward J. Modestino; Foojan Zeine; Nicole Jafari; Keerthy Sunder; Milan T. Makale; John Giordano; Marjorie C. Gondre-Lewis; Marco Lindenau; Brian S. Fuehrlein; Rajendra D. Badgaiyan; Chynna Levin; Sergio Luis Schmidt; Rossano Kepler Alvim Fiorelli

doi:10.3389/fpubh.2025.1594872

Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

Kai Uwe Lewandrowski
, Kenneth Blum
, Alexander P.L. Lewandrowski
, Panayotis K. Thanos
, Albert Pinhasov
, Alireza Sharafshah
, David Baron
, Mark S. Gold
, Catherine A. Dennen
, Igor Elman
, Aballa Bowirrat
, Edward J. Modestino
, Foojan Zeine
, Nicole Jafari
, Keerthy Sunder
, Milan T. Makale
, John Giordano
, Marjorie C. Gondre-Lewis
, Marco Lindenau
, Brian S. Fuehrlein

Rajendra D. Badgaiyan, Chynna Levin, Sergio Luis Schmidt, Rossano Kepler Alvim Fiorelli

Pharmacology and Toxicology

The Kenneth Blum Behavioral & Neurogenetic Institute
University of Arizona
Fundación Universitaria Sanitas
Universidade Federal do Estado do Rio de Janeiro
Center for Advanced Spine Care of Southern Arizona
Ariel University
Western University of Health Sciences
Curry College
JC Recovery Center
Eötvös Loránd University
University of Vermont
Karma Doctors & Karma TMS
University of Southern California
Guilan University of Medical Sciences
Stanford University
Washington University St. Louis
Jefferson Health Northeast
Harvard University
California State University Long Beach
The Chicago School of Professional Psychology
University of California at Riverside
University of California at San Diego
Howard University
Yale University
Texas Tech University Health Sciences Center
Icahn School of Medicine at Mount Sinai
St. John's University

Research output: Contribution to journal › Comment/debate

Original language	English
Article number	1594872
Journal	Frontiers in Public Health
Volume	13
DOIs	https://doi.org/10.3389/fpubh.2025.1594872
State	Published - 2025

Keywords

Reward Deficiency Syndrome (RDS)
addiction and mood disorders
dopamine D2 receptor (DRD2)
genetic predisposition
hypodopaminergia
neurotransmitter regulation
pro-dopaminergic therapy
stress induced anxiety

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10.3389/fpubh.2025.1594872

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Lewandrowski, K. U., Blum, K., Lewandrowski, A. P. L., Thanos, P. K., Pinhasov, A., Sharafshah, A., Baron, D., Gold, M. S., Dennen, C. A., Elman, I., Bowirrat, A., Modestino, E. J., Zeine, F., Jafari, N., Sunder, K., Makale, M. T., Giordano, J., Gondre-Lewis, M. C., Lindenau, M., ... Fiorelli, R. K. A. (2025). Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia. Frontiers in Public Health, 13, Article 1594872. https://doi.org/10.3389/fpubh.2025.1594872

@article{7b65da783137468ba912059994c620cb,

title = "Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia",

keywords = "Reward Deficiency Syndrome (RDS), addiction and mood disorders, dopamine D2 receptor (DRD2), genetic predisposition, hypodopaminergia, neurotransmitter regulation, pro-dopaminergic therapy, stress induced anxiety",

author = "Lewandrowski, \{Kai Uwe\} and Kenneth Blum and Lewandrowski, \{Alexander P.L.\} and Thanos, \{Panayotis K.\} and Albert Pinhasov and Alireza Sharafshah and David Baron and Gold, \{Mark S.\} and Dennen, \{Catherine A.\} and Igor Elman and Aballa Bowirrat and Modestino, \{Edward J.\} and Foojan Zeine and Nicole Jafari and Keerthy Sunder and Makale, \{Milan T.\} and John Giordano and Gondre-Lewis, \{Marjorie C.\} and Marco Lindenau and Fuehrlein, \{Brian S.\} and Badgaiyan, \{Rajendra D.\} and Chynna Levin and Schmidt, \{Sergio Luis\} and Fiorelli, \{Rossano Kepler Alvim\}",

year = "2025",

doi = "10.3389/fpubh.2025.1594872",

language = "English",

volume = "13",

journal = "Frontiers in Public Health",

issn = "2296-2565",

publisher = "Frontiers Media SA",

}

Lewandrowski, KU, Blum, K, Lewandrowski, APL, Thanos, PK, Pinhasov, A, Sharafshah, A, Baron, D, Gold, MS, Dennen, CA, Elman, I, Bowirrat, A, Modestino, EJ, Zeine, F, Jafari, N, Sunder, K, Makale, MT, Giordano, J, Gondre-Lewis, MC, Lindenau, M, Fuehrlein, BS, Badgaiyan, RD, Levin, C, Schmidt, SL & Fiorelli, RKA 2025, 'Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia', Frontiers in Public Health, vol. 13, 1594872. https://doi.org/10.3389/fpubh.2025.1594872

TY - JOUR

T1 - Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

AU - Lewandrowski, Kai Uwe

AU - Blum, Kenneth

AU - Lewandrowski, Alexander P.L.

AU - Thanos, Panayotis K.

AU - Pinhasov, Albert

AU - Sharafshah, Alireza

AU - Baron, David

AU - Gold, Mark S.

AU - Dennen, Catherine A.

AU - Elman, Igor

AU - Bowirrat, Aballa

AU - Modestino, Edward J.

AU - Zeine, Foojan

AU - Jafari, Nicole

AU - Sunder, Keerthy

AU - Makale, Milan T.

AU - Giordano, John

AU - Gondre-Lewis, Marjorie C.

AU - Lindenau, Marco

AU - Fuehrlein, Brian S.

AU - Badgaiyan, Rajendra D.

AU - Levin, Chynna

AU - Schmidt, Sergio Luis

AU - Fiorelli, Rossano Kepler Alvim

PY - 2025

Y1 - 2025

KW - Reward Deficiency Syndrome (RDS)

KW - addiction and mood disorders

KW - dopamine D2 receptor (DRD2)

KW - genetic predisposition

KW - hypodopaminergia

KW - neurotransmitter regulation

KW - pro-dopaminergic therapy

KW - stress induced anxiety

UR - https://www.scopus.com/pages/publications/105018527910

U2 - 10.3389/fpubh.2025.1594872

DO - 10.3389/fpubh.2025.1594872

M3 - Comment/debate

C2 - 41080838

AN - SCOPUS:105018527910

SN - 2296-2565

VL - 13

JO - Frontiers in Public Health

JF - Frontiers in Public Health

M1 - 1594872

ER -

Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

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