Systems biology of antioxidants

Ramaroson Andriantsitohaina; Lucie Duluc; Julio C. GarćIa-RodŕIguez; Lizette Gil Del Valle; Mariela Guevara-Garcia; Gilles Simard; Raffaella Soleti; Ding Feng Su; Luis Velasquez-Perez; John X. Wilson; Ismail Laher

doi:10.1042/CS20110643

Systems biology of antioxidants

Ramaroson Andriantsitohaina
, Lucie Duluc
, Julio C. GarćIa-RodŕIguez
, Lizette Gil Del Valle
, Mariela Guevara-Garcia
, Gilles Simard
, Raffaella Soleti
, Ding Feng Su
, Luis Velasquez-Perez
, John X. Wilson
, Ismail Laher

Department of Exercise and Nutrition Sciences

Stress Oxydant et Pathologies Métaboliques
National Center for Animal Breeding (CENPALAB)
Instituto de Medicina Tropical Pedro Kouri
Research and Development Department
Naval Medical University
University of Havana
University of British Columbia

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Understanding the role of oxidative injury will allow for therapy with agents that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia and stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases.

Original language	English
Pages (from-to)	173-192
Number of pages	20
Journal	Clinical Science
Volume	123
Issue number	3
DOIs	https://doi.org/10.1042/CS20110643
State	Published - Aug 2012

Keywords

Antioxidant
Ataxia
Diabetes
Free radical
Mitochondrion
Sepsis
Stroke

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10.1042/CS20110643

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title = "Systems biology of antioxidants",

abstract = "Understanding the role of oxidative injury will allow for therapy with agents that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia and stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases.",

keywords = "Antioxidant, Ataxia, Diabetes, Free radical, Mitochondrion, Sepsis, Stroke",

author = "Ramaroson Andriantsitohaina and Lucie Duluc and Gar{\'c}Ia-Rod{\'r}Iguez, \{Julio C.\} and Valle, \{Lizette Gil Del\} and Mariela Guevara-Garcia and Gilles Simard and Raffaella Soleti and Su, \{Ding Feng\} and Luis Velasquez-Perez and Wilson, \{John X.\} and Ismail Laher",

year = "2012",

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doi = "10.1042/CS20110643",

language = "English",

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pages = "173--192",

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T1 - Systems biology of antioxidants

AU - Andriantsitohaina, Ramaroson

AU - Duluc, Lucie

AU - GarćIa-RodŕIguez, Julio C.

AU - Valle, Lizette Gil Del

AU - Guevara-Garcia, Mariela

AU - Simard, Gilles

AU - Soleti, Raffaella

AU - Su, Ding Feng

AU - Velasquez-Perez, Luis

AU - Wilson, John X.

AU - Laher, Ismail

PY - 2012/8

Y1 - 2012/8

N2 - Understanding the role of oxidative injury will allow for therapy with agents that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia and stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases.

AB - Understanding the role of oxidative injury will allow for therapy with agents that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia and stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases.

KW - Antioxidant

KW - Ataxia

KW - Diabetes

KW - Free radical

KW - Mitochondrion

KW - Sepsis

KW - Stroke

UR - https://www.scopus.com/pages/publications/84861541395

U2 - 10.1042/CS20110643

DO - 10.1042/CS20110643

M3 - Review article

C2 - 22494160

AN - SCOPUS:84861541395

SN - 0143-5221

VL - 123

SP - 173

EP - 192

JO - Clinical Science

JF - Clinical Science

IS - 3

ER -

Systems biology of antioxidants

Abstract

Keywords

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